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Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D. Q# `: Y* ^- k. `0 \
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The deepening of our understanding of normal biology has made
$ S& ~+ ]8 b! G1 h0 F- Dit clear that stem cells have a critical role not only in the generation of complex
# c7 N8 @# D6 ~# c$ y" X1 Lmulticellular organisms, but also in the development of tumors. Recent" x* f" C# J' u
findings support the concept that cells with the properties of stem cells are integral
: F: H0 Z1 y8 s( i1 H1 E) w: Yto the development and perpetuation of several forms of human cancer.1-3 Eradication
' G) l2 t7 t. @of the stem-cell compartment of a tumor also may be essential to achieve stable,/ e7 @' i/ v! w1 ?
long-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of" C/ c6 \! y7 I% g( E! o7 ~, b+ x2 ]
the properties of stem cells have made specific targeting and eradication of cancer% s1 H' W( }" z
stem cells a topic of considerable interest. In this article, we discuss the properties
& O6 s4 @/ _2 S9 @6 r0 }of cancer stem cells, outline initial therapeutic strategies against them, and present) P7 @1 F% I+ ^$ v0 ]; n( r% v
challenges for the future.
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发表于 2009-3-24 11:30
发表于 2009-6-3 13:46
