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Correspondence regarding this Primer should be sent to Marshall A. Lichtman, M.D., 601 Elmwood Avenue, Box 610, Rochester, NY 14642 or mal@urmc.rochester.edu% R+ F9 h5 O' E, w! ^
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Stromal cells elaborate.6 U8 G9 ^4 M! D! d7 j+ }0 S
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Cytokines orchestrate.
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Signal transducers propagate.
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7 u- K b0 I( N5 wGenes dictate." c/ n# s* j) H! m* Z+ d, r5 H. u
8 `, G8 c9 P+ E N' |Transcription factors mediate. mRNAs translate., i! x0 U5 z+ ^' c- k# @7 U$ y8 V
3 j% P7 V$ k' }% C5 O, @; VProteins effectuate
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! @" J0 J3 Y/ N' rStem cells differentiate.! k0 o0 g2 l( h D4 j
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(It appears that they can also transmutate!)2 j' Z9 z0 Y. K, O
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Progenitor cells proliferate
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- B4 O0 Z; T* M- q, CErythroblasts hemoglobinate) E% M# K" N3 Z+ Z, v0 O* A. \; K
6 v2 p0 A$ R& r/ eMyelocytes granulate.+ q* J) V7 s% I; `; m
6 C5 x2 n+ C" A' ^ M" EMegakaryocytes fragmentate.
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7 Z; Y; f k% ?( ?Mature cells circulate., a/ Q( W& X+ V5 e' \/ p4 T
# _0 m3 _. ]( W( w8 T. [0 U8 B( MBlood cell counts fluctuate.
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Red cells oxygenate.& X3 g1 j# z, U' v! n, q( g
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Neutrophils emigrate.0 f/ ~) T6 e* z2 ^2 K
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Basophils and eosinophils degranulate./ G" r' T4 Y% O
6 L$ A# u$ z5 W3 e: s7 @, JMonocytes transfigurate./ Q' w$ U$ T7 Y6 O* R
, _. Q# Q% w- k9 v: {6 O( e. L4 fDendritic cells cooperate.; M$ A4 b4 p( y& s% l m- \1 ]
" s2 v; V0 c; R! }6 g$ V7 r P, zLymphocytes activate.1 u+ t; p: f. Z" H8 Y3 X7 I
6 | d; b* p6 o5 \- `$ zEnd cells disintegrate.
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Hematopoietic scientists cogitate,
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Then, they may elutriate.3 z7 ]% S; Z E, W9 A
! ^: h- F" [2 Y1 i( Q9 e mHematologists medicate,
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; a$ c7 _# Z [% jAnd occasionally they irradiate.2 _) Q$ s: `0 r0 D. _4 Q- c
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Followed sometimes by a stem cell infusate.
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They also may prognosticate,
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9 E( N" ^4 W. fBut they often over- or under-estimate.
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Now we have embryonal stem cells on our plate.: b& ^0 C7 `) M5 o% h
+ ?* L9 Y/ o6 Q) u3 xTheir use is undergoing ethical debate.+ _# C$ q& w: l; _) l& P4 l+ M
4 r; Q* F4 [- a+ ~+ S0 j9 L6 bThe point is that if one can direct their fate,1 r0 c- z7 S. V$ w# L
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Certain diseases we could abrogate.& v" _6 @2 s: f1 T9 Q
& r& t) i1 W/ C+ \6 b, I, vFOOTNOTES+ p" ?; E. |8 @
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1 It was initially thought that the author is a distant relative of Paul Ehrlich, the German chemist, immunologist, and Nobel Prize laureate whose research with aniline dyes lead to the polychrome stains for blood and marrow cells and of Alexander A. Maximow, the eminent Russian embryologist and histologist, who provided the first evidence for an hematopoietic stem cell as the source of blood cells. The latter disclosure was made in a lecture delivered to the Hematologic Society of Berlin in 1909. Careful editorial inquiry uncovered that Ehrlich Maximow is the pseudonym of Marshall A. Lichtman, M.D., Professor of Medicine and Biochemistry and Biophysics at the University of Rochester Medical Center.(Ehrlich Maximow1) |
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发表于 2009-3-5 10:36
发表于 2024-4-29 08:54
