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Nat Methods. 2009 Oct 18.【Epub ahead of print】
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. k; Z8 u9 x$ B1 ]4 D! ^6 Q. Q# S! HA chemical platform for improved induction of human iPSCs.
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.. E% t9 u. ]# d+ A
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
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0 e/ p- z* X1 I `$ CThe slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.& ?9 O: p( A+ m8 \
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PMID: 1983816- ?$ D3 ]& N) G. t/ T% [
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发表于 2009-10-21 20:20
发表于 2009-10-22 15:52
