干细胞和肿瘤很相像，they can self-renew, differentiate to produce progenitors. \6 F$ A: b/ f& Y2 y( W$ Gaged stem cell has reduced ability to self-renew. but cancer stem cell seems never age!
首先1、肿瘤是个复杂系统性的病？" x" \- I# ^# h$ n
其次2、这就难怪为何会有如此多的肿瘤假说模型能立一家之言，其必有接近真理的一面，但太局限 $ B% n& }- B6 n( Z% O/ p% M0 E" R) IIt is possible that the number of different tumor types is equal to the number of patients. 0 d+ w" B6 _7 K- n1 U' d
$ \+ \2 Q; [- T; n- y* X8 h" ?
再次3、反应了肿瘤是个需要通盘考虑的、不能仅仅局限于点、线（癌基因、肿瘤干细胞、多倍体）上的考虑、是否能集众家之长？剔伪存真 - O6 L5 `6 F/ A# ?) X: E
the cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. ) {( U8 z5 m; X8 `( Q/ i
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4、繁琐复杂现象的背后、必有其本质；不要急于求解现象本身，更应该追溯其本质；如果你抓住的是本质，应该适用于所有的肿瘤和解释所有现象，有本及末，方有头绪。& G8 {: ]! r( u2 K
5、你可能会发现，肿瘤可能比人预想的要复杂的多得多！3 E. B1 x H: h2 |+ M* v* M: v
I believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec.
It is possible that the number of different tumor types is equal to the number of patients. * t2 d1 _* b1 `
我英语较差，不知所云，$ v e. W: R7 k' x% j* |9 u
the cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. 3 W+ t( e2 L. I1 v0 c4 Y1 f- Q9 R
其实癌基因假说同其他许多假说模型都是有很多很多的纰漏和不足，都似乎在盲人摸象一般，只见局部不见整体。 8 B& [! f" q% |6 W6 J: }) qI believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec.! Q$ g# I w2 ^
呵呵，这是我看到的最为自信的话了，我还可以更自信的说，我相信我们已经遇到肿瘤所有现象中的80%以上， * w! o+ h2 [! @$ I I8 U+ O, B& w' G然而理解不超过20%.包括病因、遗传、免疫、本质等等都没有understand，都有太多的争议而没有结论。
发表于 2009-11-30 22:38
发表于 2009-12-1 09:33
