干细胞分化中的重要调控信号通路：报道与实例

kephort

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对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。- ~3 d% U4 T0 d( a5 i' n
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin# }2 m' M. m: f( |* B2 D) ~3 Z
Wnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。, p0 d) Q: U6 I$ {7 W$ Y, C% c
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1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.
0 z- @$ m; W  L8 h, F% [2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.% j4 e8 v% S5 w* I
3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.5 T: ~. G" @& _( e! m1 _- w( w
4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.
0 `4 |  D( x; ?% E7 u5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.
! q* r& F+ V' f6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.2 s0 i0 e# [8 }  D) Z; R( v$ K" }
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.
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七篇文献全文请在附件中下载。" E; n) I: N. e# {+ ]3 A3 K: ?

3 X2 v) F# v7 v. f4 _后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。: ?) m) b" {& d
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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谢谢海洋% k' C2 e* [' w0 A

9 g, R; ], k) l3 n/ }, P海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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4 V3 {0 u+ {% K  ?) j, ~2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：1 b6 M& f3 v8 u( I/ M3 U: n+ H* ?
1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.+ t* ^+ L+ U$ s* U5 m
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.4 \; ^& S# q4 z6 ?) S) b
3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
1 ~6 O! F  N  L7 [: N6 s4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.. d; F/ s. |! i9 b3 \
5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.- f) m8 a4 z+ |+ J
6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.! y1 x$ B, `- C/ A
7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.
0 d. T, a+ R) o8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
7 {* z% `% s5 k- a+ r9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.8 g2 o5 T% A# C3 d( O1 \* `. D
10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283./ C* J  A6 t/ ?9 a
11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.. V* ?3 r- `& j8 B3 b: |5 X
12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.( G5 G% S" X7 j" i, I: \$ F: M/ c
13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
) r+ S. F; e5 g+ K' \14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.
- e' u" A5 \2 P6 W  O也打包提供了全文。7 Q4 L' _4 ?( E$ f
请下载附件中的14篇全文PDF
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kephort

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; z' n2 A8 Z; }8 Z. P* X$ D欢迎大家关注、讨论细胞分化和细胞命运决定的机制。8 ^  R; q" L9 S; f+ s' @, f. `* l
也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！
& ~5 J) [" S% F, _# b5 S8 T感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。