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Non-Viral Gene Therapy1 r# O1 L9 b* _4 Q# E& G o
Edited by: Xu-bo Yuan9 Z8 x) n9 {9 [0 @5 W
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% v" m& E; O7 Z9 i6 b1 h' |ISBN 978-953-307-538-9, Hard cover, 696 pages9 U7 v5 W6 F0 w! m" C, o4 H
Publisher: InTech- Z1 b6 l1 c z$ a, ?( l
Publication date: November 2011
+ q* x3 F4 u- }5 Y/ c: fSubject: Gene Therapy; |% D( H3 b% y
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This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation.& X) A3 I1 b( L- T8 T
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Table of Contents
$ j4 O/ e% s0 P7 eNon-Viral Gene Therapy Vectors Carrying Genomic Constructs8 C7 K7 K# m' U9 ]5 T M" g
# C0 y, b" r2 i* \9 ]Non-Viral Delivery Systems in Gene Therapy and Vaccine Development) J% @, C. f: a L- |7 ]* Z
% y/ F: G6 [2 d. {0 fGene Delivery Systems: Tailoring Vectors to Reach Specific Tissues; ~2 f1 D2 r, f2 y1 [# ]% P7 t! e: k
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Investigation of Transfection Barriers Involved in Non-Viral Nanoparticulate Gene Delivery in Different Cell Lines
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The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy7 J) C; e z0 T8 O
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Gene Therapy of Some Genetic Diseases by Transferring Normal Human Genomic DNA into Somatic Cells and Stem Cells from Patients. Y7 @! L/ f$ M8 S
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Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders
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! _$ h7 R7 B' EDNA Vaccination by Electrogene Transfer. t) e* M3 N0 T
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Gene Delivery with Ultrasound and Microbubbles5 c; t' y. U+ n% t
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Ultrasound-Mediated Gene Delivery* ^4 M, K! v! U# f# a' l
1 R! H( ^9 R. a4 v3 c9 [' pPolyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity9 ?8 Z5 L% q. z, Z, O
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Technological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy( U3 }) f R2 } t& J2 r
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Cationic Liposomes in Different Structural Levels for Gene Delivery
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j& B0 a7 m; s. z# m( dNeutral Liposomes and DNA Transfection
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Non-Viral Gene Delivery Systems Based on Cholesterol Cationic Lipids: Structure-Activity Relationships6 M6 A6 J, _6 Z' |
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Polycation-Mediated Gene Delivery: The Physicochemical Aspects Governing the Process
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~0 i. G3 V9 p4 NMedical Polymer-Based Gene Therapy, X/ o3 t! o d1 N3 F
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Chitosan and Its Modifications: Are They Possible Vehicles for Gene Therapy?1 Q/ A2 m" \. ], Y0 F8 g2 e
; H [0 L) d$ H) s0 ]Chitosan-DNA/siRNA Nanoparticles for Gene Therapy! a( d+ Y; H/ e: D
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Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application& X) L; S5 a: R [
" Q- m' Z7 v* jPAMAM Dendrimer as Potential Delivery System for Combined Chemotherapeutic and MicroRNA-21 Gene Therapy) E5 s) y6 B, a
* F0 A$ ]+ t4 [5 z2 }6 {9 ?Nanomedicine Based Approaches to Cancer Diagonsis and Therapy
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; S1 \# ~+ z' ?" \Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems Y$ x, @/ Y: N& N, O
?$ _3 D: z1 ?4 E/ yNano-Particulate Calcium Phosphate as a Gene Delivery System
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/ L; B I% t- j/ }4 eModular Multifunctional Protein Vectors for Gene Therapy1 s3 A) z& \3 Y6 g2 I. s! B8 ^+ K
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Peptides as Promising Non-Viral Vectors for Gene Therapy7 f( x6 T( e! T2 ?
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Binding of Protein-Functionalized Entities onto Synthetic Vesicles
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% @" @" D6 u, yTargeting TRAIL Receptors with Genetically- Engineered CD34+ Hematopoietic Stem Cells; F) n# k* Q3 o7 ?8 A4 }" ~: K6 N& W
- O S( j; ?1 k" XPyrrole-Imidazole Polyamides for Gene Therapy: Bioanalytical Methods and Pharmacokinetics# G ~% B D3 C7 h3 w' |, @: M- |
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