|
- 积分
- 1832
- 威望
- 1832
- 包包
- 3907
|
回复 marrowstem 的帖子
3 V) b$ c; W# l, O {) f) n8 J
& V3 O- k6 E9 ~& E; a; D以我目前在这个领域的知识，还很难回答这个问题。我查了一些资料，就发表一下看法，不对的还请指正：- B) {2 D7 y5 w4 F* Z) q: X
关于clonal evolution的描述：The clonal evolution model of carcinogenesis states that cancer cells over time acquire various combinations of mutations within a tumor and that genetic drift and stepwise natural selection for the fittest, most aggressive cells drive tumor progression. According to this idea, tumor initiation takes place once multiple mutations occur in a random single cell, providing it with a selective growth advantage over adjacent normal cells. As the tumor progresses, genetic instability and uncontrolled proliferation allow the production of cells with additional mutations and hence new characteristics. These cells may leave a large number of offspring by chance, or the new mutations may provide a growth advantage over other tumor cells such as resistance to apoptosis. In either case, primarily the latter, new subpopulations of variant cells are born, and other subpopulations may contract, resulting in tumor heterogeneity. Through this process, which occurs throughout the lifetime of a tumor, any cancer cell can potentially become invasive and cause metastasis or become resistant to therapies and cause recurrence.6 L6 v- y$ }% s, d6 {* X3 k
4 b: n# U; t* \0 e8 K. T根据这个假说，肿瘤细胞是一些列的突变导致细胞发生变异，而获得生长优势，最终失去控制，并形成了不同特性的细胞群。, H! u( }1 C! N4 n/ h- G
8 u% S4 q: `6 j1 W7 `而你问csc有没有clonal evolution的能力，这个我不知道。但前面一个问题里我说了，csc产生的肿瘤组织的progenitor或许有这种能力，csc只是产生了这些progenitor，而这些细胞才是在肿瘤发生中起直接作用的细胞。* ~ p4 h$ _+ h- Y" @! E. u6 n
" p( q/ h% D! `/ e
另外我想问一句，clonal evolution假说和csc假说之间最大的矛盾在哪里？是肿瘤的来源还是肿瘤发生的机制？我个人觉得貌似没有大的矛盾啊，而且csc假说只负责解释肿瘤发生的机制，并没有谈论肿瘤的起源（引自文献的原话：The cancer stem cell model does not address the question of whether cancers arise from normal stem cells. Rather, it suggests that irrespective of the cell-of-origin, many cancers may be hierarchically organized in much the same manner as normal tissues.） |
-
总评分: 威望 + 10
包包 + 20
查看全部评分
|
发表于 2011-12-6 20:21
发表于 2011-12-6 21:48
