PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-6029
8 K) Z! a# z" S* G& e# P9 bISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
- E3 w# Y; S- i6 oDOI 10.1007/978-1-61779-612-8
( G; s9 D; w" h) N& S$ ]Springer New York Dordrecht Heidelberg London
9 l5 b6 X% g; b: {1 L" U9 ^Library of Congress Control Number: 2012931559
/ B4 w: e" W3 K& T7 s2 D5 l2 Y© Springer Science+Business Media, LLC 20129 ~8 Y% K8 i$ S2 R) f

/ `( [* P5 C) J7 M% c4 nContents7 L7 f8 B. T0 f- k& Y4 H
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
+ O% g) m  h. C. . . . . . . . . .        xi
- q+ M( Q* m/ B! QPART I   EARLY EPIGENETIC EVENTS IN CANCER
( {* x* z4 U. i3 d( L  |& p1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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Ramona G. Dumitrescu) ?% I+ X+ O: G, ]) ^0 i
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 v4 W5 i: z; T# |# q" P
. .       15
6 H6 {; E0 x# d4 `Alok Mishra and Mukesh Verma9 z( ~& v. W' z' c
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES
, w, E' W/ C5 x, Z3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35$ N1 w' L4 A$ i8 h# G
Ramona G. Dumitrescu
( \2 k  D+ @) ^+ D: r, |4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      , C1 T; a4 g0 |: o5 k$ V
47: a( D2 v$ G- q8 R$ p! D( h2 F
Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz
4 q$ a  {5 E6 f. T- _3 t5   DNA Methylation in Promoter Region as Biomarkers
5 X: _" o/ X: z$ S% s0 c& I. Min Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Y9 z- ~) E8 s2 k
. . . . .      67
; g8 L) u7 @% SMihi Yang and Jong Y. Park
0 v7 @- J% C( {  A  G6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Wun-Jae Kim and Yong-June Kim5 `: W5 h' v$ Y$ P$ [7 k5 T4 [
7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 b( S/ ]: A- `# }- W  c
. .    119, g+ ~1 d& m* [
Stefan Deneberg
) z7 t( L" L5 @1 w1 K# x5 |3 z8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 S1 s* o1 j, A: C. .     139
" j0 q, w- y" {  WAdrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor, o  x+ j0 G8 M: K
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155
" R2 h2 I) ?3 ]3 }' vQiang Lu, Dehua Ma, and Shuping Zhao
5 ?& e! _0 K& z# X. f; M# z! s, B10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 K  U& s- k' }
. . . . .     177
' j/ c- K* T7 O0 I8 C6 }( oSharad Khare and Mukesh Verma
; ^" m" Z6 }+ U6 Q' g7 q) S% O9 D11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    187
" U: ~( h+ N) j9 m* r" _% N% S& v# aJosena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham* p- r: I$ R# W
12   Epigenome and DNA Methylation in Oral
$ a* S" Y" O% f  ~1 E6 {: ^Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " u( H! x7 W% _) E
.    207, ], v% L3 O# ?& N3 U4 a
Mario Pérez-Sayáns García and Abel García-García
& P6 \& R( V7 u0 m# n5 @+ r+ {9 VMario Pérez-Sayáns García and Abel García-García# J0 p0 ?. A/ \! @9 |$ |1 Z, w

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9 f# D1 z8 }5 X" r: ?& P# Iviii           Contents
, G4 |) C9 e2 a; }: ~7 _; h13   Clinical Implications of Epigenetic Alterations in Human& c% F  j% [0 q6 s
Thoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221
( X+ D% p6 b' `Keiko Shinjo and Yutaka Kondo
0 P2 }! f) a& {2 H. S5 Y9 ^14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
& T: W  F6 i: \: E0 j* X( _* k4 @Krishna K. Banaudha and Mukesh Verma
& e; H4 }; ~! i" ?1 t4 F- e15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 }8 Y$ @" g, s7 F* y1 V4 E* U
. . . .     2535 a- |+ T  n* G- b/ W& E
L.M.S. Seeber and P.J. van Diest+ h. L% C* Z1 s  Q9 Q
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION  q3 M) E4 o  k$ F4 P& x8 ^" r  a
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16   DNA Methylation in Pancreatic Cancer: Protocols" l" z/ `. M7 X
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
+ G, C( O7 V7 L* GKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky
8 E5 H8 y9 r6 b, @1 w) N6 l# C17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
, h7 `+ }8 x3 p6 c2 EHilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills
5 y& _4 p. B8 R) T5 A& H18   Screening for miRNA Expression Changes Using Quantitative; }  ^3 ~; R( F' X. K  x  }6 ^: ?
PCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
$ }2 `  k+ N9 U) o, |$ K. . . .    293
) Y0 i* ^& E$ O1 i  @- z6 YRichard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills. h& s+ C' v' Y2 \# X3 {
19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . / d( ~. O+ L& {( F1 }5 ~
.     303
- j! {# b: d9 _' KAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor
! r# I/ v7 R- O8 O; C: k. _) M; n20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319
" Q: X' J" M# I8 L1 q, R: S$ K, JHilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills) Z0 z5 v( Y+ k
21  Detecting DNA Methylation Using the Methylated CpG
( q1 D6 B. n; yIsland Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     1 J' i5 \( Z7 ?, l* j
329! w" a9 n6 C% x0 b' d) N
Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills0 `1 o. Z# T! {5 d& q9 {

& N6 ~4 A0 h$ L8 C# S" UPART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER7 m/ K" z5 ^% `5 i5 [

# [( W1 |9 D; B4 Q: P, |22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
/ d: A* R% N, {; u3 Z$ cGabriela Riscuta and Ramona G. Dumitrescu" u! O8 n) |/ V7 y) m& j' U
23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     
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. r! E0 x% O# G! C: d; d: gUnhee Lim and Min-Ae Song, z1 B# W" i! x' C) c3 x% O$ i
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
0 y; y9 f1 _' ?, `. . . . .     377
- }0 x) \# x( Z) G! |0 r, L" cL. Joseph Su2 E' D  R+ |7 u! J; N2 s0 A
25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . .
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Sulma I. Mohammed, Sanya Springfield, and Rina Das2 g. T5 P. ]! _$ H. Y
26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . .
3 ~: A6 s! k# q! P7 {, M- C. m. .     411
  b, d* v$ c0 Y6 ^+ J( HJovanny Zabaleta  {; n8 }* y1 V9 ?6 a

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( V- ~9 m1 H! U  A: f8 m% k) FPART V    EPIGENETIC EPIDEMIOLOGY& \+ w2 b+ S3 V& j$ G

* i3 ?0 w0 f6 ]& P$ s27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline
: h& U; ~# ]$ {, I8 f* i* K$ `+ MEpigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 [: Q/ Z4 C" W8 b& A# o+ i* z
. . . . .    439
& O5 O9 b4 Q  ^- a, `2 i' w9 WKevin Brennan and James M. Flanagan7 k& U3 X+ ^/ T% s, T/ {( s
28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .   
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" a# ?. A7 {3 j$ ^: P$ DMukesh Verma
( s6 h4 s% q3 R8 N* u3 ~4 s+ mIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ' X6 g& B9 F# o+ u1 M/ s  L$ A
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