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5 {, ] u- L [3 T' \/ e4 b$ m) [9 j/ n参考文献:- ?) k! h8 a. Y0 a( y
1 Krampera M, Glennie S, Dyaon J,et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide. Blood, 2003;101:3722-3729* W( U; i& M# j$ S
2 Potian JA, Aviv H, Ponzio NM, et al. Vetolike activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol, 2003;171:3426-3434$ k! f$ q' K! B+ X( ^8 ~" R
3 Klyushnenkova E, Mosca JD, Zernetkina V, et al. T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. J Biomed Sci, 2005;12:47-57
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0 g# O% i1 k8 o% v. P$ i, E4 DiNicola M, CarloStella C, Magni M, et al. Human bone marrow stromal cells suppress Tlymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 2002;99:3838-38439 `( u1 {% L. B% n% l: y% s
% _9 ~: i0 E1 t/ Z5 Rasmusson I, Ringden O, Sundberg B, et al. Mesenchymal stem cells inhibit lymphocyte proliferation by mitrogens and alloantigens by different mechanisms. Exp Cell Res, 2005; 305:33-41
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4 ]/ y1 i, s" ^$ K, K. g# R7 F6 Sun S,Guo Z,Xiao X,et al. Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method. Stem Cell, 2003;21:527-535
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7 Maccario R, Podesta M, Moretta A, et al. Interaction of human mesenchymal stem cells with cells involved in alloantigenspecific immune response favors the differentiation of CD4 Tcell subsets expressing a regulatory/suppressive phenotype. Haematologica, 2005;90:516-525
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; W: n# X$ d; d" D* K& D3 Z, R8 Djouad F, Plence P, Bony C, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood, 2003;102: 3837-38447 u4 A. E, x5 S$ b
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9 Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell response. Blood, 2005; 105:1815-1822
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; r, ~5 }* M/ k5 D/ i- {, r10 Beyth S, Borovsk Z, Mevorach D,et al. Human mesenchymal stem cells alter antigen presenting cell maturation and induce Tcell unresponsiveness. Blood, 2005; 105:2214-2219
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1 Y. q' s" n% ~% t11 Jiang XX, Zhang Y, Liu B, et al. Human mesenchymal stem cells inhibit differentiation and function of monocytederived dentritic cells. Blood, 2005; 105; 4120-4126
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12 Nauta AJ, Kruisselbrink AB, Lurvink E, et al. Mesenchymal stem cells inhibit generation and function of both CD34 derived and monocytederived dendritic cells. J Immunol, 2006; 177: 2080-2087* q% `$ k- ^. b6 e! R! U/ Q3 h; d7 a; J$ l% X
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13 Rasmusson I, Ringden O, Sundberg B, et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation, 2003; 76 :1208-1213
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- }# b3 ^1 Z3 A y7 H M3 r14 Angoulvant D, Clerc A, Benchalal S, et al. Human mesenchymal stem cells suppress induction of cytotoxic response to alloantigens. Biorheology, 2004; 41:469-476, W- K. a4 U/ K" p
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15 Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol, 2002; 30: 42-48
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16 Guo Z, Li H, Li X, et al. In vitro characteristics and in vivo immunosuppressive activity of compact bonederived murine mesenchymal progenitor cells. Stem Cells,2006; 24: 992-1000
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5 X: ?9 H% Z+ H17 Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T cell anergy. Blood, 2005; 106: 1755-1761: g9 Y5 Q2 P3 l$ N# c
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18 Lazarus HM, Haynesworth SE, Gerson SL, et al. Ex vivo expansion and subsequent infusion of human bone marrowderived stromal progenitor cells (mesenchymal stem cells): implication for therapeutic use. Bone Marrow Transplant, 1995; 16: 557-564* f9 w" v& p% q& X
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19 Lazarus HM, Koc ON, Devine SM, et al. Cotransplantation of HLAidentical sibling cultureexpanded mesenchymal stem cells and hematopioetic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant, 2005; 11:389-398. o1 E N1 F3 _
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20 Lee ST, Jang JH, Cheong JW, et al. Treatment of highrisk acute myelogenous leukemia by myeloablative chemoradiotherapy followed by coinfusion of T celldepleted haematopioetic stem cells and cultureexpanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype. Br J Haematol, 2002; 118:1128-1131
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; A f" t& S' t1 d. K' `21 LeBlanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graftversushost disease with third party haploidentical mesenchymal stem cells. Lancet, 2004; 363(9419):1439-1411# x1 [5 `. e0 R2 s# E, W
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