[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

芷瞻

Nat Methods. 2009 Oct 18.【Epub ahead of print】1 t' p, l. Z; K5 f8 C1 t
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* j* ~- f5 X, D+ cA chemical platform for improved induction of human iPSCs.2 V& l: h8 V- g1 P1 K
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.
! x+ F" v) y; m- LDepartment of Chemistry, The Scripps Research Institute, La Jolla, California, USA.. ~/ }+ Q' G4 p2 P. f/ D* i

* b! l) l+ G, }/ c( f' K% F5 UThe slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.5 a0 I8 {- \- P

3 x) Y0 B& z0 mPMID: 1983816
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jianlindunev

学习中，感谢

好玩301

怎么下载不了了？仍然感谢

sunyucheng

ddddddd

应菜

能下，谢谢

lorey

顶！好文章

dengyanfei

非常感谢

carolshf

非常感谢

风源

感谢

mmssyyee

请问你有没有这篇文章的methods呀？我在网上下载不了，有的话能不能给我一份啊，谢谢！！！