老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"5 s& H5 i, m1 t( b, P- @1 D( `+ U
2017-12-1 13:178 }0 ]4 q4 H5 ~+ c7 x
Bioreactor in vivo would be the terminator of illness." @1 s  s) r9 k" v2 K0 i. I
2017-11-20 23:092 t( V5 `7 U$ X9 {. V* X% h8 t  Z5 Q# d  u
renew tech：剔除衰老（病变）细胞占位可以恢复青春。
+ I* R8 h/ K( b* U$ P  `* e4 U/ F2017-10-23 12:50
' b$ U+ }2 }1 ], g/ b5 ~, l魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。8 ?4 t  B: @! C! u2 k/ j+ z: T
2017-9-30 10:58
3 e: ], R+ R# @  A; h$ pLife 3.0——from decoding and coding to reading and writing6 f! a7 G) c) B& s9 f
2017-9-21 22:32
) [8 K! T" [) F1 L0 d3 m9 d2 Y& k! I理论创新：亮明立场——先颠覆，再完善
" C7 m+ n1 |# W# f2017-2-7 00:07
: A5 i4 t2 ~/ M' Q4 k  q干细胞第二定律：与细胞外基质共同构成多潜能；
. ^9 e( l. J* @5 J% T, ]2017-1-3 11:14: E# B( U4 G7 [! M1 R
干细胞第一定律：全生命周期保持增殖分化能力；
$ L% ^7 z1 O* H) c) o$ b9 d2017-1-3 11:13
2 q8 P" }3 b8 h% w# gNgAgo——Never give A guideline operated！( z9 e8 @6 y1 f, R, S3 }/ i
2016-12-1 10:09! G$ X( U0 {! A6 a
表观遗传—— 一切皆可改变  一切皆有可能
  _3 y' u7 e, L) X( w2016-8-17 23:37% M5 m2 c, d* b6 Z$ T
子曰：吸血鬼疗法——养儿防病 养孙防老
- L( T' o: A" B$ H- O# @$ I* H2016-5-23 12:05
0 R( V; k, u* A: G+ E7 QNgAgo——Debug tool kit for mammal cells- m/ ?6 n5 {- n& E
2016-5-9 13:09
1 I7 h, C6 s2 `# R5 a: A+ t2 W公理之外 皆需证明； 科学命题 皆可证伪。# }+ ~( Y0 A7 S! j9 @' l! F
2016-1-2 00:20
5 A1 k9 M# p! D) `6 ]低氧——破坏线粒体功能、诱发炎症、导致基因突变, M) v: G/ M; _
2015-12-16 20:19
) y3 |# k$ B+ x( \* [0 _- \癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。/ |9 Z; G/ t) o5 Q* v
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)# Y8 u: U. n- I1 U+ u" T5 u; P
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45), z9 d4 o3 A0 W4 s
hcoohboy: 3ks~ (12-24 16:45)/ E: Q  q+ |' d2 @- |
2015-11-18 15:54# b! X. c$ z% h/ W/ a* ?2 v8 R
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。0 j! o3 G( H0 M: L5 k
2015-5-20 14:13% j( T5 Y& U/ g( U
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学4 E- k$ S# y" j! f8 @$ L
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
7 {$ w! x9 w( h0 E: N" nsunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
3 I% ^7 A# _" T- @. M) l" S2 r* k2015-4-21 16:46
- y) l/ |* P7 p) tsearch and research is just disassembling the creature.
  J; V( m$ ]$ {1 m" b0 X2015-4-7 17:01
* Z# ^0 s% o- ^! z( o! k; V; k7 Yselection is  the act of intelligence
  E( ~9 y/ d% ^* C6 X$ r+ S2015-4-7 13:499 j5 {( I7 N6 S3 M
Genome fusion create neoplasm
1 f; _4 s2 i- I: l2 I! r2015-1-20 13:10
# d8 d  u! V1 F2 p, u- U' D8 ySTAP——Stupid Trick  Against Professional 6 N; f( k" f5 Q3 [* g
2015-1-1 19:29
& ~# x% r* p+ H- _information=structure=negentropy5 o9 T( w) ^& D2 i: h
2014-7-22 17:363 Q: Z* V! g  A% a) k/ D7 p
Natural mutation does not result in new functional genes 
0 P0 o6 z. t/ _/ q3 e% [* Y2014-7-3 14:06
: ^* i. l# {  W( g) Clife is wisdom creation instead of natural evolution
% l) P1 o8 I; [" Y6 I/ k: V2014-3-27 09:33
8 C) [' D- P5 vlet us explore the source code of life !: W0 T+ ~8 i: V- d8 g% z
2014-3-11 13:114 A% j- n2 g, }) j7 G
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
1 \* w- }! ]3 _3 z7 @. X2013-10-7 23:068 F' u/ s6 ~: L
induced abortion would give the key for curing cancer 
; o7 J0 m$ K, w6 G, Z& v; w+ I2013-10-2 23:33
* T6 `/ d+ B) R6 d“key breakthrough” in molecular biology are entertainments4 U1 [/ J) W; H& }3 {: C1 Z& t
2013-6-16 11:50
2 @3 Q3 V/ S& X: f7 w* @( SRules Of Living：trial-and-error exploring，survival takes the legitimacy$ |6 ~3 J$ \5 C6 b: w1 p) a+ Q. g
2013-6-16 11:27, n1 P/ E0 o+ D  I/ Y
Life is a set of debuging programs. S# b  V/ w* b/ M/ p
2013-6-15 18:40
* e: C! n/ }0 R" Acurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells/ O5 u/ {* S6 e+ y: d, b# S9 n# ]
2013-5-2 08:54( U4 w) \7 ?8 d5 I6 u0 N* z
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
; L4 v3 R/ n: \% }2013-5-2 00:51
$ M/ X$ r8 S# r8 f- Nvirus is the messager of  the universal life network
( {) G. n: K+ ]: c1 J2013-4-18 14:33
6 x9 I( L& h$ ?% |# y# S+ `6 yGenetic information doesn't improve cancer risk prediction8 q# h& D% M0 B  q# A5 K( z
2013-4-1 09:20
: d# q" I0 W' |' k: Q3 vThere is no early diagnosis of cancer，but early prevention of it# g' I0 l% T" f0 Z
2013-3-27 09:172 k* B  ?& K& Z
hypoxia maintains stemness or carcinogenicity- P) I  t% f, o5 j
2013-1-2 05:21
" k8 u( t" G: X& Q2 r3 Kcancer is the living fossil records on origin and evolution of human being5 y% q( b+ @0 w9 L  _/ H# f
2012-12-9 23:31
! i3 [8 p/ `- k3 |7 F# ainformation island results cancer
  x) _: v2 w- T! u' z2012-12-9 05:23. ^" E3 ^+ ?  o
life is digital game' L6 z) e+ ~- o, F4 x( ?' I
2012-11-10 00:175 {0 G5 }! s' I5 a& P
cancer ——severe abstinence reaction of cells to niche addiction
' a& ^8 b# H# h: T" c: A3 O2012-9-28 12:11
- \7 V( M* b9 G+ z  f未来生物学终将回归物理(熵)及数学(分形)的美感
5 f6 v! n' l0 r9 q/ `% hbiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)4 A. R1 f) H. K; \8 B8 U
2012-9-25 21:22
, ]- F: ?$ R& B0 N! E& Xmembrane holds the key to life
: j& u, H" ~. I2012-8-19 20:24( T, v5 w, e0 Y. U# B8 `
Cancer is the default state of cells
* q. b! g0 v. L) z, m6 t8 T5 ?' V  L, L2012-6-26 22:17
$ D! t/ a* t( G# U8 ~) ], }# T) |mainstream cancer theories could be overthrown！
' Q7 E: h2 T6 j% I, @2012-6-25 15:433 L; p  Q- ~. _
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...9 z, [3 D7 o" @; e/ p" k4 H' U
2012-6-7 09:363 |* `% n* G# V! m
every living organism connected with the water， one cell one world
! l& M  ]% |7 o0 _0 H- n- U/ ^2012-4-19 22:06$ F6 i4 h0 t9 A
chemical structure of cancer cell determines it's biological function...
1 k7 `$ N  ~& x0 G2012-4-7 17:56
! c% g; |7 C! c/ hMann tracht und Gott lacht
$ O& t. ~+ L# F( z$ t0 b+ g4 T2012-3-24 21:34
9 F5 B+ x0 [( p0 r8 _Darwinism or genetic determinism is a fairy tale！3 t. h3 O. k! S
2012-3-13 15:18+ k- d9 m9 Y& J9 _' T) ^$ I, x
niche isolation is essential for cancer speciation2 V4 f1 o+ l1 \8 x* d0 M
2012-3-12 12:07
- a; V# k% c" p' S8 i8 d1 FHybridization Creates New Species，Mutation results species extinction
4 [" v( Q# k. T* @; T7 d9 n2012-3-11 18:21
& Z) w" N$ ^/ A& P; iROCK may join the niche reprogramming...2 _6 a7 F  v, L/ O' C% ~
yuhaoze: 这是篇文献吗？ (3-9 10:41)5 }$ U" u# y+ p
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
  M) n  F  m1 X1 _+ pyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)$ y( r  L- V; M( q- U
2012-1-19 10:52! C5 e5 C3 o) |! A& C- b3 b7 D
oncogenes are pseudoscience* g1 v6 S, }, v" e
2011-12-29 13:55
' y* `, X- y& w; V& q  fgene mutation leads to variation or extinction, not new species
! ]& U: \* a" r, `! J2011-12-29 13:28
4 J7 p  K- G( B; v7 B9 Foncogenesis is non-Darwinian event
# p$ m' A& s, g# ?2011-12-28 22:56
/ C! n) D' \; s8 y2 Idisorganization activate neurogenesis activate oncogenesis   : Y/ |$ F9 R( l
2011-12-22 23:38
' @: [" u  s6 _+ AMSC is cell feeder，tissue scaffold，immune firewall and biological glue
+ R* k9 h5 L* p% d2011-12-19 19:46: W/ D2 G5 |3 j) m
cancer is Noah's Ark（species carrier and life explorer）, ^% O4 c4 @0 `
2011-12-10 09:46
& D) y) Z2 Q$ _! Z+ f: q& l* F% ~7 |cell fusion create new species, gene mutation induce variation
; Y) U1 t/ B/ B! V+ {2011-12-10 09:360 g9 M( V0 ]) T
GVT will be cancer terminator， Cytokine storm will be cancer preventor
! w$ B  G4 d. g+ [, Y! L% }5 E9 j2011-12-8 12:56
2 Z6 d/ H, I( L0 [  A9 F( Rcell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
" y- F' c5 b, z5 H+ o3 T2011-11-27 14:54
5 z; Z+ \% {+ d( ?$ }Cancer is between protozoa and mesozoa， not metazoa...
+ V# U. [9 s! @! d( m3 E& }9 s2011-11-27 00:25
0 Q7 ~5 u0 H. l" X' acancer is neurological disease！ haha，I got it！7 S1 C& e0 x8 x, B& l  w9 p- g3 U
2011-11-22 22:06
0 B5 G% |7 Q" P/ v0 O, \you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
" y0 i+ ?$ r( H; c, S  B' f% \2011-11-12 11:27
+ Y, A% A- k, Q# S: `! B0 r, @cancer is the ecological invasion of hacker...
/ J* {, f+ B. A; N! O2011-10-5 10:31
* D# ]$ `4 x# _0 @7 r/ d. a7 YmicroRNA is  negentropy？8 S: T: n! R8 |% Y3 i, O
2011-9-24 00:48
6 ]" Y9 w6 T; {3 w% C% C" ?( |' r9 xcancer is the social problem+ P5 G; p; w, f* E7 `
2011-9-9 23:33
& l/ s: K8 a4 sScience is the games of nobleman or madman
; _3 U3 b( o9 }" v/ t2011-9-2 15:03
3 {- Z7 u2 `0 u8 ~" ~cancer resulted from disturbance of biological liquid crystalline state of ECM0 b# \- `  |/ a6 Q( O# B4 X
2011-9-1 20:138 Q& `6 h1 g6 p
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...7 |7 A. l6 k& e
2011-8-13 00:370 ~) S) _, L* s/ l3 t1 j6 b3 B
Second recession is coming？& N) @/ n( e) g1 ~' }- C
2011-8-9 23:58
( Z; x% v5 o/ w6 hcancer may be from sexual reproduction of somatic cells.
$ ~0 s) g& M' ^& {7 P, @1 w2011-8-7 00:162 |9 G3 [' C6 G% n8 d
who determine gene？ genetic determinism is fatalism！
* A: k8 j( s" m2011-7-30 11:26
5 X. R( Q% l- _niche reprogrammabllity is the key of solving cancer problems...
* j, E. N5 @1 osongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
2 r" ]2 B9 P0 n9 g5 nsunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)3 j4 R- N5 c) A! @4 f- j
2011-7-24 01:24" Q: A( d2 R7 u* H" o9 K
cancer results from acquired genetics alterations.
9 H) F  d2 x/ Q1 Z2011-7-20 21:37$ j6 f: @0 t+ ?1 `1 F
CSCs are the low differentiated cancer cells in G0
4 J% g1 C% `  m1 r% M9 f2011-6-29 16:30
' P- v; ]+ Q% q- @1 o; @; h9 L4 ?. niPS future——in vivo direct reprogramming ...& s- a6 |6 x& |; T
2011-5-31 15:200 j* @, h+ Z' d; r" U. x
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
9 H3 M  S4 ~5 \9 v/ H$ ~2 h. Z2011-5-31 01:28
1 P; U! S* ^* u/ n+ oall the somatic cells of Mammals are totipotent ！  N& \& O/ L( ?" |% ~
2011-5-22 22:22
) O2 ^' C) [8 ^7 J* ^miRNA——The manipulator of  cell fate！
3 \$ O8 z! A& K" r; X3 S8 `5 w* y2011-5-20 20:211 R! v9 |7 C3 b$ d& K
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？& r' y6 L/ q4 L/ }7 ~0 d
2011-5-17 12:381 j& L/ \! ]0 D9 G) P
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
) e8 F# ~3 _- k' s% `/ ^, _2011-5-11 12:31
7 o, N5 D5 e- k* m: z" Ycancer results from cell dedifferentiation...$ N4 z6 T, g7 I# t) _
2011-4-28 18:07
4 X" ^; E6 s! I+ ^+ J, ]1 G( cdifferentiation——asymmetric cell division ！
: V% Z2 ^7 a' e& M0 i& L2011-4-28 18:04
4 t  n. r( M( O% u4 q* {6 j; {! Q, Ncancer origins from the regenerative cells！
7 U8 A. B! b8 F6 [: S% y) I2011-4-28 17:525 Y) e$ Q& {+ n+ k# {! |
Proliferation is differentiation potentiality！9 n- v& }8 u8 Q5 X
2011-4-28 17:49
& J1 X# V( U8 T3 r/ b+ n3 hiPS——the key of Pandora box！
; C+ d- q) p5 c2011-4-27 22:36
4 t" j  n( ]( z8 m/ Y& }Aristotle— "The whole is greater than the sum of its parts."5 o- v) M, y. c: ~
2011-4-27 00:200 S. g+ ^  W$ r- R( a7 S
cancer——atavistic cells
: t- \  I4 x/ h; ]1 A' g# F8 q2 J8 L2011-4-20 00:20
$ }5 b4 |) L( O7 V8 t1 ccancer——cellular atavism！
# z: Z1 p4 N( w0 E2 K5 }! p5 W' f2011-4-20 00:18+ d8 a2 a% n' O! v
cancer——evolutionary ancestors of mammals.
, \9 x1 ^) W4 t) ^* h& M2011-4-20 00:09
' s3 b+ k- B" D" O肿瘤是细胞自组织缺陷的产物 
+ @' S4 `0 D7 O( O2011-4-17 01:410 v* {6 T) v9 I6 @4 _0 B
cancer——Metazoa 1.0
  z3 J8 u  v6 X4 H# Q1 C1 }: L2011-4-17 01:00
3 `- d0 V! |7 Q9 n4 aUS——the Axis of Evil！5 H4 z- ^- `3 m* V$ X% V( h+ N* t& S
2011-4-4 01:19
) G6 o& d. {0 q& m- ?. |9 }美国是世界的邪恶轴心！
1 c/ m+ h  O) d" f$ J5 qsunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
+ T/ ?9 i3 K9 [# @$ _* t1 t& K- G2011-3-22 19:06
# d& G, \% F/ c7 v5 \; s  tteratoma is derived from endogenous iPS！
, t6 U4 y4 C5 O% \6 q- B2011-3-15 21:44
9 N6 K! |3 M- U& b* ?; m- g7 r8 nips is a luxury gambol on  
: s5 W$ h6 d* e0 w2 c( v! }0 L2011-3-3 14:50
0 ~- W. F% w8 Acancer is intermediate of species evolution2 W' Y+ W7 ~; f5 {, i& ?
2011-2-12 12:29
6 B4 G5 u" ^0 d4 A5 a- s7 tstem cell now is on the eve of coming medical revolution
. A& v4 v) H& O2011-2-12 11:20
" {- \& K) ?' @; T' ~Inflamation is the reprogramming process of somatic cell in vivo！
& X' W& R2 x$ f2011-1-31 14:49
, {( }+ L" i5 J+ bso-called medicine is niche regulator！
+ Q- g) \2 y6 y7 k' A2011-1-23 21:45
" S4 |+ c& l9 Z+ Q6 v  kendogenous iPS is the cancer initiating cell！
4 F2 g5 {+ k0 x( f2011-1-17 16:47
9 R5 o2 Y( \2 v9 o% J' F" hcancer is unicellular organisms！
" h6 J5 O" ^2 i; [- m2011-1-9 22:04$ q, Z# k0 C+ W% }; {0 u5 d, ?
Pandorabox Has Been Opened: j$ N8 T: ]$ @) _" R
2011-1-7 23:24
. G- {5 m9 }- E* jiPS is the Emperor's New Suit ! 
8 Y$ a  t- u7 Q1 R. T1 k2011-1-5 23:50
+ S4 C& @0 o1 W1 e( A# W3 Mcell-free is the final solution of stem cell therapy
% W' K, H2 w: ^* D. k- A& f2011-1-5 21:46
; o, [% U" H% L) L/ W1 C9 A9 _niche is telling the story of stem cell...
. W& g# }# G0 U5 S8 _+ {5 ^2010-12-29 17:32% O; p0 W6 C. R5 F
cancer results from reprogramming of somatic cells
; z. P( ]# f& J" @2010-12-25 18:56% d9 d& c9 {5 X, r) z6 D& k
cancer——good cells in bad niche！* v3 v" _  o' U( \; n* E- Z
2010-12-25 16:02: M+ e6 f) C' N
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！4 v* |5 }* q  W4 B* `
deron: 灰常同意，有相关文献么？ (12-19 09:41)
; l$ O. ]0 r% P0 k1 c  p) |sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)  l2 `* f" U: S) e' b- A# q' c
sunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29), n: L' j6 a- T& k2 n
2010-12-18 15:546 |6 c* d" y* p: i6 l
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
, w! ], O6 W5 m5 K/ C& V+ W7 s2010-12-15 15:07
: m& h( b$ ?2 S! }( ~* @1 k1 M; `) G7 ~老狼的记忆——大洪水6 F( H/ j) }& C: t' R
2010-12-13 23:25- m/ B) L: f1 |; G1 E* g0 T
can cancer randomly differentiate into norml cell in vivo  / K7 A' A  \% l, f
2010-12-13 22:33
7 g4 }8 P, b  }" l0 `+ f+ ^" R+ M+ Nomnis cellula e cellula
) t3 r9 o" w( f2010-12-12 09:28
. R$ p$ n; S% _' g# o; C8 y8 b$ AStem Cell ——The Origin of Disease
5 m5 E8 x, Y' t+ I2010-12-12 09:27
1 O4 O% Y8 S$ n  N

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