SCIENCE心脏祖细胞文章

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Cardiogenesis and the Complex. m5 F- z7 S# L: ^
Biology of Regenerative% W* s6 K7 i0 b5 Y* A9 _2 e' T
Cardiovascular Medicine
0 y) K1 D/ w% h7 W7 C8 i  q" oKenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3+ P  D2 L: E7 p- b
The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
. A2 b; }0 A% Q# M( f. Zcells. Understanding the pathways that drive the formation, migration, and assembly of these cells4 A! @- a* k& X# A! h) e. u" h; ]
into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is
/ Y2 D; L$ M+ K9 [2 G8 R! ea central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
! F0 p- Q5 m; I) V. Bcardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These8 e8 R4 @" d1 e; x' E' J1 `- M- a
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and$ w; M+ \! \# }* T, ]7 w1 X
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering4 y7 o* ^2 y8 w) B
technologies with patient-specific cardiac progenitor biology holds great promise for the& K: O; U8 K& D2 ~; B6 B. |/ I
development of human cell models of human disease and may lay the foundation for9 |# N. Q3 Y9 D- \
novel approaches in regenerative cardiovascular medicine.

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