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Emerging models and paradigms for stem cell ageing
3 a7 e) u/ {, R, @4 C6 QD. Leanne Jones and Thomas A. Rando1 |' Q$ y8 q l
Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.
) M! l" Z7 R0 d% a& PHere we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction. O9 J8 W0 G1 e" u3 w& ^' ^5 a, r+ G) y4 z
in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal. _- ?. u' ^( h# _( R
and aberrant differentiation potential.
6 l6 Q3 W5 x8 r"Nature cell biology 13(5) 2011"
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