《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
: `1 Y% M3 S7 ^: M7 x1 {4 `On the cover: The combined activity of neurons in the brain generates
/ X: ~% y+ z* y3 M- Foscillatory rhythms, or “brain waves,” that can be detected by 7 ]9 \6 u& h0 {  z" L+ {4 X% S; y
electroencephalographic recordings. Verret et al. (pp.708–721) found that these $ U1 x' E8 X' ?' u& Q( o
brain waves, which are represented on the cover by an undulating pattern, are - j0 N) b& g  r! U3 f
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
' }9 d$ }. U+ h8 m, M0 W5 p5 vto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 0 g) A+ j5 u0 P: Y$ |
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory 2 i6 p0 u" x; X0 R" o& m
rhythms and memory in AD mice, offering a new therapeutic approach for 5 X9 M, u, d! ?" K. q( N
potentially treating cognitive disorders. The image was created by Arantxa 3 f) _* u$ c  `3 L) s
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
5 K' x  i5 A5 I8 W2 s; Z/ l# i(electronic recreation).
3 B$ G/ `$ R2 k( v0 n[hide][/hide]

menghy

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cytobiology

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