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 # J. b5 j6 A7 a8 r3 S/ A
Volume 78, Issue 4On the cover: Neural networks control 7 E% p# ?* `/ O% H- e; j' l' Z/ q
intrinsic encoding of the circadian clock. Circadian pacemaking in the
# U4 ~" L( ?: @+ t1 I2 Msuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and ( F% C3 F: e; _( ~3 n
intercellular properties, with the latter still poorly understood. In this issue % l" H; v" n6 S8 J
of Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level
: i) i K' p3 y/ a1 tencoding of circadian time, showing that specific activation of Gq-Ca2+ axis in
& a. E. L. ]8 P; X9 k. Drestricted SCN neuronal subpopulations reprograms encoding of circadian time by
4 d6 L! K5 h$ _3 j0 Z% u4 Rthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic
" W) G% I+ ^: t/ L) H: mconnectivity. Concept by Marco Brancaccio; cover illustration by Joanna
' B. A P. U% zWestmoreland.( M" u+ z6 y' l# c/ ]
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发表于 2013-5-23 23:46
