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Volume 78, Issue 4On the cover: Neural networks control
( g: Q( u7 s( \* xintrinsic encoding of the circadian clock. Circadian pacemaking in the
5 Z ^" S! b2 h& U m0 k3 F6 csuprachiasmatic nucleus (SCN) depends on cell-autonomous clocks and
7 k2 j$ K1 B3 n5 A y3 R4 G% e5 \intercellular properties, with the latter still poorly understood. In this issue
2 s1 N, c7 D" l" lof Neuron, Brancaccio et al. (pages 714–728) shed light on circuit-level / s, `' B% _( d4 j* U
encoding of circadian time, showing that specific activation of Gq-Ca2+ axis in 7 [+ F' }. Q: c4 B. k$ a1 c {
restricted SCN neuronal subpopulations reprograms encoding of circadian time by
" e! |, G/ \; y% S+ Cthe entire circuit. This circuit-wide reprogramming requires intrinsic VIPergic / p, b; w. i4 L+ P2 j, j
connectivity. Concept by Marco Brancaccio; cover illustration by Joanna
' S; l3 d6 V& G, c) ?( Z; w9 JWestmoreland.6 R6 F2 R6 f& c1 @4 |+ y
* ^. E* M% F: b; V3 l# F1 @ J- x |
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发表于 2013-5-23 23:46
