1998-nature-Dendritic cells and the control of immunity

andylee824

   B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic* t' O( r3 ?7 n+ G% b  u
cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to* Q/ s7 v! c6 p3 L! w5 I
lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also
& w% O2 {& P9 v, a7 O* K3 L# Ttolerize Tcells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once
2 S9 u9 ]- w5 e8 ^a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell$ w6 M" n( E! i$ [$ N; `
biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the7 t9 ^* ]1 m  l3 K( b
immune system.

andylee824

自己顶一下！

andylee824

自己顶一下！