老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"* S0 Q; e9 ?) j7 @7 ]
2017-12-1 13:17
2 _5 q! V  T7 y; S* i0 C+ \5 m8 cBioreactor in vivo would be the terminator of illness.( R4 H$ n+ i& Y' s8 r- p
2017-11-20 23:09
, N! j; r2 [: F; w+ ]renew tech：剔除衰老（病变）细胞占位可以恢复青春。
0 u+ |' X0 y! c. J* T) m) ^' B2017-10-23 12:50. y1 B  o$ M( F
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
$ m- h; \# j' i" T2017-9-30 10:58" E2 l* A) h" Z
Life 3.0——from decoding and coding to reading and writing
  [8 ]/ N; c% A) |) N2017-9-21 22:32
/ w, N6 b3 Y4 l% c2 u* g! g理论创新：亮明立场——先颠覆，再完善. A' l0 A5 Q5 D; X
2017-2-7 00:07
9 q. {- M5 ^9 J$ h# a7 E% B) d干细胞第二定律：与细胞外基质共同构成多潜能；. a. L  Y/ b) b
2017-1-3 11:14
- T1 |; g! |' M0 e) m( q干细胞第一定律：全生命周期保持增殖分化能力；" F& ~6 z5 z# n1 \' e
2017-1-3 11:13
* k  Q5 i1 f3 D: X9 n+ L  kNgAgo——Never give A guideline operated！) d# Z* d: f4 \6 Z( y) ]) Z1 t5 o
2016-12-1 10:09
4 }, V! Z5 e6 N" j% \表观遗传—— 一切皆可改变  一切皆有可能! ]! u+ K" ?9 m! z) c0 ?& C
2016-8-17 23:37
; Q1 w2 B  _2 n5 y子曰：吸血鬼疗法——养儿防病 养孙防老, `/ n  i1 v& M/ j/ R6 {
2016-5-23 12:059 B5 L8 A$ d7 x) e
NgAgo——Debug tool kit for mammal cells, R) C5 K; ?: d0 \; u; h$ p+ \
2016-5-9 13:09
5 Y9 t3 o4 @+ c+ H5 U公理之外 皆需证明； 科学命题 皆可证伪。
. t7 a4 s1 t, O  _- a) E2016-1-2 00:20
7 e4 T5 G' m0 @; ~, c) }1 Z低氧——破坏线粒体功能、诱发炎症、导致基因突变
) E3 n2 V; C1 b8 j0 t2015-12-16 20:19
2 M( p; M+ @/ l8 f* D+ ]+ ?7 r癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。) p  R1 |- q, n6 Z" V
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)2 W0 g: ?% P# x% t( u
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45), C5 I# r$ m: E* ~
hcoohboy: 3ks~ (12-24 16:45)" o: }; I/ ?% L& R
2015-11-18 15:54
  R; h. [4 k9 v1 ^抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
( a. n, |( D; ~  e' j/ v) l2015-5-20 14:13" V# d9 g8 J+ P8 W7 k! M9 L. P
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学
+ B1 f  \! @% z4 |# khelong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28): i2 L1 a+ }6 |  v
sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)$ H5 U' t& o7 w# K" t0 o/ p0 g# s8 [+ o
2015-4-21 16:462 _6 I. C6 e0 D; Z5 c/ W6 U( x8 V! y4 [
search and research is just disassembling the creature.
- P+ [2 b( {% ~% K' w2015-4-7 17:01* d. l6 K* C0 u% a# H% V4 a: e7 e
selection is  the act of intelligence- t+ S  p  h, _' f+ g! W
2015-4-7 13:49+ b! g$ ]2 q" }( ?
Genome fusion create neoplasm
- m1 n2 X, w7 q4 S# c; z. J2015-1-20 13:104 I' E5 ~2 R9 r" O" [* C8 M
STAP——Stupid Trick  Against Professional + D4 i! l3 ^, m) Q
2015-1-1 19:29+ `1 [, `% Q; U  `) O
information=structure=negentropy! k2 K9 s. ]) B. ]4 i
2014-7-22 17:36
: c+ R( ~1 O: H0 Q+ K/ tNatural mutation does not result in new functional genes * G% M* f. Q! \0 \7 b
2014-7-3 14:06
" k* t- y6 _1 H+ D/ Flife is wisdom creation instead of natural evolution
; B4 s/ {3 K( o* I" q. b9 W# x; b+ i2014-3-27 09:331 z( d; d, g# ^
let us explore the source code of life !
, K0 B; A: m6 A1 j4 K2014-3-11 13:11
/ C& `* j6 E  Z" Fbio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
2 F8 L9 p- ^8 \# }( W2013-10-7 23:06' r4 Y0 c& }6 T$ s* A6 s7 a
induced abortion would give the key for curing cancer 
0 l5 G$ f9 w5 C; @; \2013-10-2 23:33
' z; ^8 f2 y9 {' {; e“key breakthrough” in molecular biology are entertainments
( d3 m) J( H: p5 i2 t* k2013-6-16 11:50
3 e) s. `3 p6 n, N8 I+ l+ `9 DRules Of Living：trial-and-error exploring，survival takes the legitimacy/ U3 i% j! i! M/ ^( t% i
2013-6-16 11:277 I. G1 o0 x" h3 W* B- A0 D1 ?
Life is a set of debuging programs- x! o' K6 E2 l/ }. U+ i
2013-6-15 18:40
# z; {  {4 k. k4 P/ D4 `current biology is closed，destined and agnostic，it is  the only contribution is to kill cells: I3 M: z: U. M# Y0 }, c
2013-5-2 08:54- ]* \  b) a5 N' C
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
: |+ G" t+ U' b2013-5-2 00:51; ]) D  `9 c! _# A  H
virus is the messager of  the universal life network3 ~* K7 a  T4 f) M2 s
2013-4-18 14:33* w! I1 W, B% M
Genetic information doesn't improve cancer risk prediction6 F: G* N! s. I9 M
2013-4-1 09:20/ }. p2 I' ^9 d- u
There is no early diagnosis of cancer，but early prevention of it# v+ f% {# M' f8 t
2013-3-27 09:17
0 P0 ?6 o4 a$ @; {  @$ {hypoxia maintains stemness or carcinogenicity! x$ Y+ C9 d1 D8 A, s. |
2013-1-2 05:21% ^! e4 N$ ]) I6 J+ |+ j+ C
cancer is the living fossil records on origin and evolution of human being
& U% d( T# w/ o+ F! r2012-12-9 23:31
- X0 h6 R0 w. g3 D8 Q& Minformation island results cancer: ]; R! Z8 r( L1 q
2012-12-9 05:23! _( q0 C9 M6 M0 n; X
life is digital game& ~* B# s* k& a
2012-11-10 00:17" E# F4 a8 N3 |+ q$ B( W
cancer ——severe abstinence reaction of cells to niche addiction
/ X8 p7 q# Y/ |4 }2012-9-28 12:11
7 I2 P& v2 _+ x8 z5 H6 x  P7 C未来生物学终将回归物理(熵)及数学(分形)的美感
) ]# F0 d3 T! B4 Q8 O* Obiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)( Y9 f" k. h6 C7 ~4 V8 V2 L! Q3 d
2012-9-25 21:22# S4 F% X$ C7 _! I$ M" K0 v
membrane holds the key to life
$ k& K- }$ d) f# {2012-8-19 20:24
) m7 n7 t' @# x" h9 R2 j3 P$ d- wCancer is the default state of cells
$ a2 ~9 y4 ~; n, M; K2012-6-26 22:17, Y5 e+ j& Q  K: j/ T9 y- P6 p$ [3 n
mainstream cancer theories could be overthrown！# E+ _) `* ]* K% f
2012-6-25 15:43
) z% U9 t4 X6 d# R8 A" R4 ^carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...+ ?) o. L" T; W3 t7 Q& z
2012-6-7 09:36* h/ I! d; t" w0 b) I3 ^8 @
every living organism connected with the water， one cell one world
! \( r) U  G- L2012-4-19 22:06
5 @+ P- ^! D- Y, Y1 H/ \chemical structure of cancer cell determines it's biological function...
4 N' p" a, c% {" C2012-4-7 17:56
, k. ]& i! m# |2 ~' f, r( ?Mann tracht und Gott lacht
- a3 m- K+ b& X7 z5 y6 M( Y( p2012-3-24 21:34
6 c, x% l3 m# jDarwinism or genetic determinism is a fairy tale！( P! }) b9 l- p* s2 ~6 d3 }# U5 u
2012-3-13 15:18) ^+ V8 B7 l6 A9 N9 }
niche isolation is essential for cancer speciation
% p5 k% ?8 [2 E2 Y: c2012-3-12 12:07) g+ }) @, L4 ^
Hybridization Creates New Species，Mutation results species extinction
. u. t; u6 U( R* @+ o2012-3-11 18:21! w. K% w1 w/ f% ?
ROCK may join the niche reprogramming...
0 A% Z0 y- g3 k2 D0 ~8 \yuhaoze: 这是篇文献吗？ (3-9 10:41)' J1 m0 @4 `5 n" J4 Q
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)) t- x% @. k3 Z
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
6 N/ m/ O1 y; V2 T2012-1-19 10:52# T! i6 I" S' O+ H! t  ~
oncogenes are pseudoscience1 d; h& T( r* d" E1 a
2011-12-29 13:556 ?6 q' F6 a6 _, a9 W, M6 V5 O
gene mutation leads to variation or extinction, not new species% U: ~7 _8 [. F1 d* _! r7 g
2011-12-29 13:28
) X# I% [+ n9 {6 _( G  ioncogenesis is non-Darwinian event
: L# L1 b( G4 q& W& i2011-12-28 22:56
6 A% [- ^7 G4 @disorganization activate neurogenesis activate oncogenesis   
  Y8 b9 T) ?2 E7 B0 c; _2011-12-22 23:38
) a1 a4 e! _4 T! iMSC is cell feeder，tissue scaffold，immune firewall and biological glue
6 l! w( P2 H: L  R2011-12-19 19:460 ]- N" f& n4 e7 a0 H+ n
cancer is Noah's Ark（species carrier and life explorer）; E5 K+ j) j1 c2 i! F
2011-12-10 09:46
8 n5 j0 a: ~& p, }- Wcell fusion create new species, gene mutation induce variation$ r9 g- n) B4 p& G0 c( I
2011-12-10 09:366 N& A9 I3 s$ k  \  A* O
GVT will be cancer terminator， Cytokine storm will be cancer preventor3 h( h6 p# V9 E9 I7 j& _% W
2011-12-8 12:56
9 @1 O6 x/ Y% ^1 {4 _9 `cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
0 q! N7 U  J* a2 s4 G: m" C) X- c$ v9 l/ w2011-11-27 14:54
5 \; l. y5 U5 o9 Z+ J! vCancer is between protozoa and mesozoa， not metazoa...+ T7 @+ s4 {* |7 f. h
2011-11-27 00:25
* N" L: B2 m3 F& u' K6 X5 Tcancer is neurological disease！ haha，I got it！
, s) C7 X- ~0 Y* t% e' B7 O" _/ M/ B2011-11-22 22:06
- \6 q* ~6 T) ~7 i. o# R* q6 Qyou are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来$ z8 ]9 }* z# x2 u
2011-11-12 11:27, ^% s% o8 f4 U1 q+ ]4 g
cancer is the ecological invasion of hacker.... A  E, r9 ?5 j# G; w1 `% f
2011-10-5 10:31
8 {" c! F% T' U/ L/ BmicroRNA is  negentropy？$ L9 q" @9 [7 b! I! ~4 e: k  Q+ o4 C
2011-9-24 00:48  e3 c5 M: k  z( s3 F. k
cancer is the social problem
% _7 m0 N2 [9 u: D2011-9-9 23:33
9 j6 s5 `) `9 U0 n2 I, x% TScience is the games of nobleman or madman7 P# G8 X3 }) Y6 R0 U9 ?, m
2011-9-2 15:03
0 {- G% C! S" X! i! e  `) B2 Q! Pcancer resulted from disturbance of biological liquid crystalline state of ECM4 @; [$ O6 c# E: f5 M9 V7 M
2011-9-1 20:13/ K1 N5 \2 W4 n3 ^' G
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...4 M  w% [) B# P% T! [: P' b7 f% |* N
2011-8-13 00:37
1 Y5 G5 E6 q, F- I, y* L0 `Second recession is coming？
6 X, T) W. p; I2011-8-9 23:58
0 X  k9 h) m+ P1 O' {cancer may be from sexual reproduction of somatic cells.- O4 O% W  _; R. @6 P
2011-8-7 00:16
9 h6 u/ r- C$ lwho determine gene？ genetic determinism is fatalism！  p$ T9 m* n6 {; N
2011-7-30 11:26
3 H; i5 H7 b* r6 qniche reprogrammabllity is the key of solving cancer problems...
2 ~  ~1 J. x  e0 t% D  nsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)( T) [& O' J- B4 w; }
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54); `- ]; @  j( J" T, M+ E/ d, x
2011-7-24 01:24) d+ }2 I, T1 r+ p0 g8 c
cancer results from acquired genetics alterations., x, R! W% O$ U9 M! b# c
2011-7-20 21:378 U  y7 b3 L+ J6 K) @, X8 x2 E
CSCs are the low differentiated cancer cells in G0
2 o  o+ P  y/ n2 G2011-6-29 16:308 K9 _! s  y7 `( G  O
iPS future——in vivo direct reprogramming ...$ s7 T2 a7 V7 i+ Z, A! I, ]+ a. z" L
2011-5-31 15:20
9 C6 H' h# y1 t  M: aniche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
: P! f# c! a  y, V3 X  }2011-5-31 01:28
8 y9 {2 D8 z: [( v, k$ w. ], ball the somatic cells of Mammals are totipotent ！9 u; ^' t4 A1 ]$ V
2011-5-22 22:22
! n: r+ Q+ r: Z4 v- u/ n& |miRNA——The manipulator of  cell fate！
' g- n, @# M" v, g8 j2011-5-20 20:21
" V$ R* p* S0 u4 y《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？( C0 R2 {  w$ ?1 V0 T) u' D
2011-5-17 12:386 |# p" k4 M- e. W
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！" Q/ z3 n# A! W  ?: V
2011-5-11 12:31
2 g0 m* K) `0 Kcancer results from cell dedifferentiation...
$ L' k* W/ c2 ^2011-4-28 18:074 `) i2 N* y; ^7 O: ^& P
differentiation——asymmetric cell division ！
5 I( m+ B$ U8 U- m( V, J1 L2011-4-28 18:043 |& n* g9 K: D3 a, h& B+ N5 Q, j
cancer origins from the regenerative cells！
% U5 z2 A/ s$ X& R7 m* ^" R5 y2011-4-28 17:52
5 F1 @" u% v1 a0 qProliferation is differentiation potentiality！
* X6 H: H) h  l9 a" e2011-4-28 17:49
+ b2 Y8 R" q* ]! `iPS——the key of Pandora box！
- }" [7 y- e; J9 ^  A' |" t2011-4-27 22:36
6 e4 |6 n# C2 p/ g7 J/ eAristotle— "The whole is greater than the sum of its parts."
2 m" [$ V/ j- a2011-4-27 00:20; h0 Y- j' S: u: L( |% s$ i
cancer——atavistic cells
5 X! v) n( h8 ~9 Q" Q$ b. [5 V) B2011-4-20 00:20) e6 [8 l  t7 t/ x1 ~9 c
cancer——cellular atavism！, r+ `$ z9 \- {/ k
2011-4-20 00:18% M4 i/ D/ x4 _8 q' w- R
cancer——evolutionary ancestors of mammals.8 |) [" I7 P. {& d
2011-4-20 00:09' M! `3 I7 w, q" P
肿瘤是细胞自组织缺陷的产物 
/ O  L, i: ]" M, s. s. r2011-4-17 01:41
1 t2 U8 [& y( t6 hcancer——Metazoa 1.0
+ j: E6 x6 c3 B# P3 s3 j3 j2011-4-17 01:00
, R9 u% O4 N. X: k& U) ~2 Q# CUS——the Axis of Evil！0 Z- U" Q% r' |7 r. h. c
2011-4-4 01:194 z- Y4 s  G$ x/ N
美国是世界的邪恶轴心！% F1 b; ~9 [; Y% _( ^. ~! ]
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25), B/ b% a% J8 j* l
2011-3-22 19:06) ]4 g( R9 C$ F( X6 `5 X2 a
teratoma is derived from endogenous iPS！
1 n6 h3 A  ^% W' |0 Q) ~% t2011-3-15 21:44
8 b+ S% q: p" X" r& \' @ips is a luxury gambol on  3 B% a( n, S* u. p* N
2011-3-3 14:50
+ p5 u* z6 O) g) m# ]" q2 U2 ecancer is intermediate of species evolution: P* E5 N6 U* I6 n6 p$ M
2011-2-12 12:29; U- b  k/ j, f- B, S8 q* ^# L
stem cell now is on the eve of coming medical revolution3 [4 t/ C+ p' }0 a& G
2011-2-12 11:20$ N8 X3 w# l) l& @
Inflamation is the reprogramming process of somatic cell in vivo！
; ]$ Q4 r5 i7 ^% W; J! g! p2011-1-31 14:49
- R' K% l* @8 P' nso-called medicine is niche regulator！
* V8 S' m0 R! f+ y- U4 f  I* n! r  i( h2011-1-23 21:45$ j' b5 t' _4 `5 h
endogenous iPS is the cancer initiating cell！
& Y# ^6 s- ~3 ]! {( ~, h2011-1-17 16:47
5 x. l1 O# Y8 y7 q% [1 m4 M# Hcancer is unicellular organisms！
; N8 n; Q' |. w% M2011-1-9 22:04
( ?( V( R$ U( Y- x  z2 V  r0 CPandorabox Has Been Opened* Z0 a! E- Y) U; [2 t
2011-1-7 23:24! v7 E3 n! Z& v4 M
iPS is the Emperor's New Suit ! 
  T6 R" s1 d/ q% X' J1 B$ d2011-1-5 23:50& k2 m5 n" J* L
cell-free is the final solution of stem cell therapy
5 _( _) Y' C6 t9 h+ O- U2011-1-5 21:464 h4 V* T3 @5 b* v1 l9 S
niche is telling the story of stem cell...
1 y' f* V$ ~- ~4 U2010-12-29 17:32
5 J6 X- A  ^$ k) r# \3 G9 U, R* l. Zcancer results from reprogramming of somatic cells
5 e$ a1 l  o8 j" M) T) c' {. \  N2010-12-25 18:56+ W8 o) K: l! g6 H5 J, L; {
cancer——good cells in bad niche！
: Q: N9 p* Y  a4 a( X2010-12-25 16:02$ T) R1 h- y8 D3 w9 R& L7 a
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
, [, x. F2 N& ~5 U/ {' _9 C( \deron: 灰常同意，有相关文献么？ (12-19 09:41)& W  J9 i" i- O; N7 K
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
# o" K0 A: [+ {' V% xsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
" ^0 r- [6 g( O+ A- v; n& e2010-12-18 15:54/ x$ I3 `0 U5 s+ r( t6 ^  B
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！5 F+ p' {. y# O3 ?+ z5 g
2010-12-15 15:07
5 K  E% S* L9 i老狼的记忆——大洪水
2 O" I# g0 v- Z7 W5 G* c% G2010-12-13 23:25/ s, G7 u4 I- a8 I
can cancer randomly differentiate into norml cell in vivo  / y% {8 W% D5 W, l& H, _2 X1 I
2010-12-13 22:336 @; u: w5 `4 O* m
omnis cellula e cellula
. z! H1 g. i; w- [9 _) g2010-12-12 09:28, P9 ?- I8 H, ~* f
Stem Cell ——The Origin of Disease$ g! n& H* O6 F, w' }1 u* y4 Q; H6 {* `
2010-12-12 09:27
' X) P2 E( o3 \9 `: m

sun_happone

这个必须赞