老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"5 ]. y$ H; t0 E1 k
2017-12-1 13:178 b  F& C3 p9 B0 Q
Bioreactor in vivo would be the terminator of illness.
9 q) Q. B1 ^/ \/ a5 ?, ]2017-11-20 23:09% s) X* Z" p6 H! j% s) M- R
renew tech：剔除衰老（病变）细胞占位可以恢复青春。
, f( d, c' Z! j7 H& y& H2017-10-23 12:50
3 @* i; R! [0 L# w9 b魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
2 x3 }& {" J  K6 E2017-9-30 10:58
3 r( ?# q2 x8 r9 h, V! U: a# [Life 3.0——from decoding and coding to reading and writing) o' Y$ |) q! T% e& p  B
2017-9-21 22:32- ?7 q4 h$ U% r& f9 j) A
理论创新：亮明立场——先颠覆，再完善0 j1 l( |! O8 P  h0 H# C4 Y9 [
2017-2-7 00:07
5 W! K& u! b! n7 U) E6 t; y干细胞第二定律：与细胞外基质共同构成多潜能；
6 W4 T. d; X3 X/ X2017-1-3 11:14
9 O" S: j8 S+ A干细胞第一定律：全生命周期保持增殖分化能力；+ m; }8 }6 K2 K
2017-1-3 11:13
$ u, O6 ?1 ~9 J6 P5 N$ \( p: QNgAgo——Never give A guideline operated！
" g, z4 y- U4 E  C5 {2016-12-1 10:09
3 D" D/ P  T2 q表观遗传—— 一切皆可改变  一切皆有可能
2 P& I/ w' |5 g- L. A# y8 K2016-8-17 23:37
4 \! I& J7 U/ W4 X( Q. m- t) x子曰：吸血鬼疗法——养儿防病 养孙防老4 \8 z7 P7 u0 n* d& r! f
2016-5-23 12:05
) _% M3 k8 T( D6 f' I& m7 T9 GNgAgo——Debug tool kit for mammal cells# C  t8 f8 `" }, O. q7 a' e
2016-5-9 13:094 h' H3 p) j- ~- `
公理之外 皆需证明； 科学命题 皆可证伪。
+ s! h* ^% h  v9 K/ v* p# {2016-1-2 00:20
, Z) S% O  L  J# D0 C低氧——破坏线粒体功能、诱发炎症、导致基因突变% V* |5 @  P8 G( K) V+ w  u
2015-12-16 20:19
9 v* O( Z8 `3 y" g, j* B( d癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
# V% V/ F7 g" Ghcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)* A2 i* t; g! m5 a! z& P2 j2 b& |
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)0 P( T6 [3 q9 B: o- i; F2 M
hcoohboy: 3ks~ (12-24 16:45)0 `7 i( g: V# y8 i  ^
2015-11-18 15:54
$ M/ @/ @/ Z* Y; B+ z抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
% L8 p) I+ W4 Z9 u2015-5-20 14:139 x6 M( S) k' i" E) v6 q( u
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学0 r3 u0 Q2 ~4 ^. o! Z
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
3 f( t: Y  @3 L% a2 Z+ Q9 _sunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
7 m, \  ?7 `( I/ I1 i- X2015-4-21 16:46$ x! q0 ^, p6 f7 j- U. I& M
search and research is just disassembling the creature.( {5 ^! [) v( ?' O& L5 f$ n3 C5 L1 g8 C
2015-4-7 17:01
0 L; A" M+ c  L: rselection is  the act of intelligence
2 R9 ^, ?5 ^; _+ w' @, `2015-4-7 13:49/ H) K9 K; S% A2 k
Genome fusion create neoplasm
- k' ?; J0 B; G! v2015-1-20 13:10
3 i  G$ Q) c. r# ?  wSTAP——Stupid Trick  Against Professional 1 D1 c, q9 e8 K7 J6 Z& ^
2015-1-1 19:29% o3 @6 y! G# ^7 C1 t3 j# j3 ]
information=structure=negentropy
% P5 Q9 ~/ u) W* j. H! `2 y; ?& h2014-7-22 17:36& U! _% X7 Z( v* J
Natural mutation does not result in new functional genes # q' N+ P1 w: ~' d4 y7 y
2014-7-3 14:06
) m; t$ ]1 X7 e" k, a4 Hlife is wisdom creation instead of natural evolution& I; w, R8 C3 `; G1 \( Z! u. F
2014-3-27 09:33
7 e- n+ I( f+ ~& t( [" Alet us explore the source code of life !! E/ A$ K# l8 D( F/ i" F) Z/ y
2014-3-11 13:11! V2 g( L. w* }7 F9 B  p$ c
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.( G" O0 E: {' N2 Z: x
2013-10-7 23:06
& C! ?1 `" l) V$ z- o. A- d" g3 }induced abortion would give the key for curing cancer 2 l2 f$ t# J* a: }# [7 k% M
2013-10-2 23:33
% h& E! D" B# D9 A3 v! ^“key breakthrough” in molecular biology are entertainments
& b( }) c$ ~! u0 W0 W. z; o2013-6-16 11:50- {3 s+ f: Y& V
Rules Of Living：trial-and-error exploring，survival takes the legitimacy' F3 E7 Q/ N! K* `3 G0 C* v3 I
2013-6-16 11:27
9 t3 g8 C$ _, R5 WLife is a set of debuging programs
* C" w. k+ c" H# X& j* S2013-6-15 18:40
7 c5 B" |: d6 w5 E+ N$ F: w- y0 wcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells; ^+ C2 {7 X. ^6 ]& W! h/ ?( C
2013-5-2 08:549 k0 t; f$ N' W0 V5 b  a. H
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
( c4 U; t0 T5 _1 k& U4 C2013-5-2 00:51
: @" C$ i) w* u  r6 O  Uvirus is the messager of  the universal life network5 h) g7 X0 W2 F: V. O% k& x7 }) ?
2013-4-18 14:332 O& a% ^# [+ @7 f7 ^9 ?
Genetic information doesn't improve cancer risk prediction
- F+ R" J! k5 P, M2013-4-1 09:20
6 A" I  m( X' F# w" J: zThere is no early diagnosis of cancer，but early prevention of it
3 v9 y- }, z) u0 B# i2013-3-27 09:17- V# G' w$ g: R+ n  v* ~! B
hypoxia maintains stemness or carcinogenicity! G, H2 l4 \1 o9 y) K
2013-1-2 05:21
' e; Q) n' F7 p& Y5 `+ x( Icancer is the living fossil records on origin and evolution of human being
+ T3 T# e6 }* A4 ~; K) H% y$ p2012-12-9 23:31
4 v: e0 j- ~& c: O% @information island results cancer
; Z( P5 ?! s. a2012-12-9 05:23
& J$ U. Y. w& Plife is digital game+ \. C3 S# e( O2 C2 ~3 R
2012-11-10 00:17
8 L: a# M# Q! O" v% w% tcancer ——severe abstinence reaction of cells to niche addiction% E: X' @5 C+ ?" y6 M/ t* k
2012-9-28 12:117 b: o& z3 D5 E2 [4 a
未来生物学终将回归物理(熵)及数学(分形)的美感* U4 f4 ~2 p4 V$ V5 S' U
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)2 M' ?3 d& e2 [% I3 n% n
2012-9-25 21:22
0 n/ _: [2 x% H' A/ M& F* W8 x* h2 {9 kmembrane holds the key to life
! c/ x: t0 ~4 ?% c+ [2012-8-19 20:24: `- p1 z! C2 [9 `) z6 v
Cancer is the default state of cells
- [3 x; I+ n- p' C2012-6-26 22:17
  Q% B: y4 c! ~  g  ]5 h2 Rmainstream cancer theories could be overthrown！- d- x3 i& z6 }4 N! ?3 o2 b
2012-6-25 15:43
! Z( ~/ }6 t- O0 s/ U: q5 A( wcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...% J4 k+ ^* ^5 x. k
2012-6-7 09:36) t: X: Y0 P- _
every living organism connected with the water， one cell one world# u, b9 d! G' U6 A( n5 v! \
2012-4-19 22:06
+ O. W! _% G( O; }. F! v  Vchemical structure of cancer cell determines it's biological function...1 g0 U5 h$ }7 Q' |/ |% e) t
2012-4-7 17:562 u/ W- _( i- P, T8 X7 P- b; ~! k
Mann tracht und Gott lacht8 l* X% m3 T! G7 m3 u8 z9 ^
2012-3-24 21:346 t+ ~8 l) F) \+ W/ W8 A) e* d
Darwinism or genetic determinism is a fairy tale！* A8 l9 N* `% U( m5 e
2012-3-13 15:18, i) e+ S( C( f  P( F/ v
niche isolation is essential for cancer speciation, E* j' [) m7 x
2012-3-12 12:07/ ?2 P0 a; h2 m$ Z/ `. [: S# B
Hybridization Creates New Species，Mutation results species extinction
* I3 F( W" Q3 r( @2012-3-11 18:21
$ _3 ^* K( T6 W% j" ]: u- GROCK may join the niche reprogramming...) c5 }7 _$ B; X# h1 |- ]
yuhaoze: 这是篇文献吗？ (3-9 10:41)7 j) u2 c: K$ c* r
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)( L! E4 J; D$ L; m' D
yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
+ h& v' r# D, @8 \1 @8 N2012-1-19 10:52
- ~: z( Q# M/ C# w4 m- @: q+ Noncogenes are pseudoscience
: A! c9 ]5 ^1 d6 |& p2011-12-29 13:55% K1 v/ e' ~0 ~
gene mutation leads to variation or extinction, not new species. V# I- v* F# n) I  ^3 u
2011-12-29 13:28
7 N: h) f, v0 [: B+ }. honcogenesis is non-Darwinian event
0 g2 A; t" P1 f" Z4 ^2 ?" B& q4 |0 f2011-12-28 22:56+ @* z* q7 g9 F9 m1 ]
disorganization activate neurogenesis activate oncogenesis   / X) k! N; o2 G9 X( P
2011-12-22 23:38
! m: F! B" O% e* N1 |" e) PMSC is cell feeder，tissue scaffold，immune firewall and biological glue/ C' W1 L" J9 _9 v
2011-12-19 19:461 x+ U1 T0 j1 c9 y( x: q
cancer is Noah's Ark（species carrier and life explorer）4 M5 V+ \" m( v7 c' a2 X
2011-12-10 09:46! n$ c( _: O. d  s2 w
cell fusion create new species, gene mutation induce variation
# h% x1 G& f4 c% Q2 E. _7 N1 M2011-12-10 09:365 J1 B! q7 h: O- J1 S% N
GVT will be cancer terminator， Cytokine storm will be cancer preventor
  C/ ~1 u/ q2 k9 ?) l( x+ A$ X! h2011-12-8 12:56
: I7 A, ]$ N& a1 ?7 Acell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;2 j8 l) q, `3 j: ?# U& i
2011-11-27 14:54' t- C- |6 s& M8 T$ I! @, a- `
Cancer is between protozoa and mesozoa， not metazoa...
8 u1 m: y1 G0 N4 G. }+ G2011-11-27 00:25" L" r1 q+ q2 {
cancer is neurological disease！ haha，I got it！
5 t  s& o! N3 h& _, _2011-11-22 22:061 K, m) Y- x8 h7 u- D
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来0 L6 ]* a  R7 y9 q4 S
2011-11-12 11:27# [, @, ~$ F' @) Y! k& C4 q
cancer is the ecological invasion of hacker...: ~/ _: F( N) ^3 N( z3 r
2011-10-5 10:31
# S0 ~* m/ n& l) \2 ]microRNA is  negentropy？: m4 t9 t4 J, `1 g) E4 D
2011-9-24 00:48+ B3 c8 G$ ], |( ~1 S
cancer is the social problem  e' s3 y6 z; p0 X
2011-9-9 23:33
8 Y+ P  U$ b- f# }Science is the games of nobleman or madman
1 d+ f. R1 M2 Q# m6 X* |& H- l2011-9-2 15:03( U5 E( _" t- o
cancer resulted from disturbance of biological liquid crystalline state of ECM  y' T: `4 F6 Y; e9 ^
2011-9-1 20:134 e- a$ Y7 [2 g3 D
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
1 P- }- r3 F% V0 m9 f& U2011-8-13 00:37: m, f$ X8 z+ ^- z0 ^( [7 {. p( g- X
Second recession is coming？
4 \# l% V5 Q: r) b; Z2011-8-9 23:58
) L" F6 q0 Z7 m+ e! Scancer may be from sexual reproduction of somatic cells.( ~% T5 O, \) ^7 ?- O. y  F
2011-8-7 00:16
5 j/ p7 @! x3 L' ]who determine gene？ genetic determinism is fatalism！
% J6 K9 t" E$ M" \$ r( {2011-7-30 11:26
; K) L+ k9 O. K" S4 xniche reprogrammabllity is the key of solving cancer problems...
! c+ R9 i, j! I, R: t2 vsongtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)3 F* _8 I( }+ a0 h$ u
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)5 O7 p3 m! b0 w, Q# ?
2011-7-24 01:24
& W* v- |4 J6 A* ccancer results from acquired genetics alterations.
- E1 g2 O" K  k) d, P2011-7-20 21:37- J7 t- }# k: D9 M4 ^- z3 v8 P
CSCs are the low differentiated cancer cells in G0
, O) P! d" C0 a! ?7 O2011-6-29 16:30
; ^% q4 o! H* _7 ?: HiPS future——in vivo direct reprogramming ...
# E' v& T" @4 K2011-5-31 15:204 P/ H4 l# s0 W( P+ V/ T: q2 e8 ]/ J- N
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
" c) e% o1 Z  B& c6 q6 v3 h2011-5-31 01:28$ t" F; i, [0 b# c8 h* a6 m
all the somatic cells of Mammals are totipotent ！
+ F( X, d* s4 {/ ?" y: P  `/ j+ d2011-5-22 22:22- B/ `) P6 ~7 X5 j! y
miRNA——The manipulator of  cell fate！6 Z- b3 l& Z5 q: f
2011-5-20 20:21
8 _. k, B0 R6 x% ]《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？$ M: J, P9 l  U0 z
2011-5-17 12:38# ]9 L; e8 g7 `% X
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
4 d! Y% E/ M" s8 _2011-5-11 12:31: p7 U+ V; q$ W8 \
cancer results from cell dedifferentiation...8 c) r. d2 s( k
2011-4-28 18:07
: j4 G& x; r& n) `differentiation——asymmetric cell division ！/ c' r% g6 _4 q
2011-4-28 18:04
# l2 e6 w" }; }1 ^cancer origins from the regenerative cells！
9 f3 S# V+ Z+ K9 ^2011-4-28 17:52/ }9 v# ]/ A  ~( D3 X5 y
Proliferation is differentiation potentiality！7 O2 ^6 s- m8 |  w
2011-4-28 17:49
* V' R! I' u/ v1 H5 ^iPS——the key of Pandora box！6 W( J1 _7 [6 _- Y* J, U
2011-4-27 22:36
- Z! A+ u# t" G/ @9 P: qAristotle— "The whole is greater than the sum of its parts."
# o# V; [# M0 x% N# l, Q3 p! V4 Y2011-4-27 00:20. ^- f% @5 o# E9 Y  D
cancer——atavistic cells
; }1 O! @$ d: h2011-4-20 00:20
9 R; P  {$ H0 k* r& E/ Tcancer——cellular atavism！
  C  O% y* K6 q/ B# w8 W9 w8 l2011-4-20 00:18" }; k0 m# C$ p0 Q1 B
cancer——evolutionary ancestors of mammals.5 Q. J9 A! h6 }  r( Y- T
2011-4-20 00:09# r% x/ o9 E- {8 g
肿瘤是细胞自组织缺陷的产物 
( ^6 k+ q) k* Y- e2011-4-17 01:41: J! Y( ]' O  ?
cancer——Metazoa 1.0
. S4 D: M: R" g; _' O, n+ |8 c2 C. ?2011-4-17 01:00
  Z9 A0 |! m$ @' F4 bUS——the Axis of Evil！
6 n% |5 i6 `! b7 m7 s2011-4-4 01:19
2 e8 P4 R# c7 Q5 N7 f8 Z美国是世界的邪恶轴心！! }( {, j, A" _1 a- k, m3 X0 s
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25), \* s" O6 k! }( ~' l% G
2011-3-22 19:06! R- U, t# y5 z1 o" k1 `
teratoma is derived from endogenous iPS！3 U4 [0 Z, J1 @5 q9 Q
2011-3-15 21:44, q9 o4 G; {0 |( W* ]
ips is a luxury gambol on  
  ^" M. t- O* e, E1 Z) _% x2011-3-3 14:508 A3 A6 c! M0 p  g7 O6 k
cancer is intermediate of species evolution
4 k3 f! k. `- a, h/ q7 d% y7 H2011-2-12 12:29
% e; l. {1 S; Y; H2 F- Z3 Tstem cell now is on the eve of coming medical revolution
6 b0 |$ S: i; [4 [' P. G2 h  |2011-2-12 11:20* e: ^! P) N5 t+ f" V+ |+ c) Y0 M" m- G
Inflamation is the reprogramming process of somatic cell in vivo！
" D4 K" x- ]  z, }6 x& l2011-1-31 14:49
$ l2 t) a2 B- L* U0 n6 j. wso-called medicine is niche regulator！' Q- J8 Y6 x: H" _% f/ G0 l
2011-1-23 21:45
2 D  ^. X) F, J( {& Cendogenous iPS is the cancer initiating cell！( Q- N( _( B1 t
2011-1-17 16:47
- m0 r8 O* e+ q# ]cancer is unicellular organisms！: j& D) k& n0 M# y9 H2 L
2011-1-9 22:04
( G3 j* E# V2 I  e' ?Pandorabox Has Been Opened+ d# m: m- j; d( R; E
2011-1-7 23:24
9 ^3 r3 g( I, ]  Z6 W8 giPS is the Emperor's New Suit ! 
0 r* z* S* u' x' t2011-1-5 23:506 t) I" l4 u7 G- D2 |
cell-free is the final solution of stem cell therapy
1 y4 x# ]- b: W7 |5 B- Q2011-1-5 21:465 {8 `+ I& _1 A; h( R
niche is telling the story of stem cell...; |% e' k7 I# v3 \; z
2010-12-29 17:326 h/ R" P5 I, I4 r
cancer results from reprogramming of somatic cells
+ ]( c) y8 N" T$ i9 r0 l  h4 S2010-12-25 18:56- a- f9 r! I; W9 b5 t
cancer——good cells in bad niche！  }$ ?: `# P) f0 f
2010-12-25 16:02
- {9 _8 F3 L% k- f+ e" vcancer无罪——制造产生罪犯的土壤才是真正的犯罪！4 p- s0 V; N- [$ K- q. X$ b
deron: 灰常同意，有相关文献么？ (12-19 09:41)9 R8 N: n/ O* m# P" \
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
% o4 S4 x+ y3 ~# h( [2 i( P2 Q5 \( Hsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29), m* R% k; k/ @  ]4 }
2010-12-18 15:542 F# V% {/ }! g, t- P! l
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！" O+ k5 P5 T! ]" x' [$ \' C+ X
2010-12-15 15:07  D5 w+ Q. s% H
老狼的记忆——大洪水
" T" O5 P  F- H5 W2010-12-13 23:25
  d& h( m8 B0 Q& o. Q6 d* f9 l& Vcan cancer randomly differentiate into norml cell in vivo  9 {& n9 F1 p) X6 R/ I: r0 ]
2010-12-13 22:337 L; r# p. S' _+ l  B- r9 q
omnis cellula e cellula% Q& n) B7 b( b, g" K* H
2010-12-12 09:28
! N7 L3 r( E0 k; g6 ^Stem Cell ——The Origin of Disease/ W  c# d5 ]9 ^, B: C
2010-12-12 09:27# e. _* R+ h( A

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