老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
; L9 w- D+ X* j/ U! r2017-12-1 13:17
8 n1 V: m% x1 B! X' OBioreactor in vivo would be the terminator of illness.
$ h6 d4 N3 J3 V9 F( _* ]8 K2017-11-20 23:09+ ~$ |  z5 C% h; `: S$ }
renew tech：剔除衰老（病变）细胞占位可以恢复青春。" z4 g! h( q$ R
2017-10-23 12:50- L2 D; u+ E) G7 D8 j9 ]) Z4 Y! T
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。* F. t1 ?# [' g, k& ^
2017-9-30 10:58) o$ K: M' w! x
Life 3.0——from decoding and coding to reading and writing
; P) N3 V+ u+ ~# n2017-9-21 22:326 s" x* f0 X8 B; x2 j
理论创新：亮明立场——先颠覆，再完善
" L% ]* K) i5 V# Z* H2017-2-7 00:078 q" O+ J' V* d0 U7 ^) H
干细胞第二定律：与细胞外基质共同构成多潜能；
( X# G) ?$ P$ h9 t- L* C) G# S  Q! x2017-1-3 11:14& h1 l' J+ @, r2 s* q$ y
干细胞第一定律：全生命周期保持增殖分化能力；/ ^) ?' R! F3 w' Z1 j; r6 i
2017-1-3 11:13
0 m8 R5 {8 g& N& |" m5 L' X9 G3 pNgAgo——Never give A guideline operated！
' j, {8 i% j3 p) S$ u% K& M/ E! U! N2016-12-1 10:09
! Y( Y1 o2 R1 t1 v1 S表观遗传—— 一切皆可改变  一切皆有可能
, O5 z/ j0 @. }6 R! R2016-8-17 23:37$ M4 t  o1 b  W2 ~: W3 W4 ?
子曰：吸血鬼疗法——养儿防病 养孙防老
/ L6 m# Z3 m9 O/ S2 A2016-5-23 12:05
, A% o! r! c/ Z2 YNgAgo——Debug tool kit for mammal cells, J& l4 O( M5 V* B5 b: |
2016-5-9 13:09& h) L/ P( Z- z9 l& R8 J
公理之外 皆需证明； 科学命题 皆可证伪。
( p0 b" n3 I- o# R+ {  w6 w$ ?3 x2016-1-2 00:20' {0 Z2 u/ k# p/ [  K9 b: D
低氧——破坏线粒体功能、诱发炎症、导致基因突变
) R, ]; V/ n* s1 \8 m, Z- s! v2015-12-16 20:196 J! o& {+ D+ X2 Y
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
% U8 y& I0 B0 s/ Dhcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)6 Y6 {9 `" b0 }) N5 W
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
- d+ {/ H. S* A3 ]+ F' R, Shcoohboy: 3ks~ (12-24 16:45)
% y0 I9 M" I) ?& F+ [2015-11-18 15:54; x, @' E6 W% D. @/ `/ V, g
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
) _3 O( [( |) P6 L0 n2015-5-20 14:13) e/ n% D0 a" u# h" ~. B( h
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学# H: P8 L1 ?" y7 _* o! _: m& _
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
) p5 F$ L4 Y1 P( @8 {% Qsunsong7: 方向对头，努力总会有结果的 (4-21 20:05)6 A' E  N" L% i" }
2015-4-21 16:46' H7 _0 ?6 c* ]$ O/ n' ?
search and research is just disassembling the creature.
, ~0 U9 I7 k5 b2015-4-7 17:01
4 J$ D& H; J3 E+ _, d  [selection is  the act of intelligence6 k7 _! K  ^  A; ~! w$ s. p
2015-4-7 13:49
# m) U: D) v& ZGenome fusion create neoplasm5 \" g6 C" Y$ B, f
2015-1-20 13:10
, C% h' l- ~  H5 E6 y- ?/ zSTAP——Stupid Trick  Against Professional   C& T( U/ D* K1 L1 {
2015-1-1 19:296 f, h* m% D, [: t, N! ?
information=structure=negentropy
( D0 l% z5 M2 E* j8 u9 t9 ?2014-7-22 17:36
# @/ T- U3 G! p5 g. F4 F3 k! CNatural mutation does not result in new functional genes 
, a+ t! Y, U) F1 N3 \; X8 X, t- `2014-7-3 14:06+ a9 E) X9 W: E9 C
life is wisdom creation instead of natural evolution
0 e' c- S9 T# |2014-3-27 09:33
8 W6 n( Z: S+ o9 f$ `3 o% Qlet us explore the source code of life !
6 Z8 f: j8 z8 V; o* \2014-3-11 13:11: ~6 Z3 Z' p+ q- b
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
; [5 a  C' D7 F2013-10-7 23:06
& f8 J9 A+ u- Y8 m, Z- ~. c) V, S! tinduced abortion would give the key for curing cancer 6 L# w, Y5 r+ ^
2013-10-2 23:33
/ B9 F. @# _9 y8 l0 I. w“key breakthrough” in molecular biology are entertainments
6 D! c' |2 k& Y% T  B2013-6-16 11:50) }- q" _) W; a8 n$ O" Y. \# y
Rules Of Living：trial-and-error exploring，survival takes the legitimacy
6 e# G1 s3 V* G. F2 d2013-6-16 11:27
; X& X$ v: |1 |Life is a set of debuging programs
5 i  v1 O4 j- }+ y4 A4 G! ?2013-6-15 18:40
3 \1 y  ^( G, v& q; k9 Scurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells
  v7 f9 \( q; X. ^: N, @2013-5-2 08:546 ~8 v) G: w; d5 |' A6 v
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales3 k; ^, e, K# O0 m6 h
2013-5-2 00:51$ a2 o' H# ~, a# {. a: Q0 [$ c
virus is the messager of  the universal life network
! G+ m2 T% c0 a2013-4-18 14:33
) m* h1 n% @4 Y7 }* ZGenetic information doesn't improve cancer risk prediction# G( y- o6 }+ Z1 l: Y9 h+ A# C
2013-4-1 09:20
# ]% G- T% B6 P  G$ J- E8 f0 D. ]! gThere is no early diagnosis of cancer，but early prevention of it
! n3 S" R! |! Q1 }9 v  A# J$ h2013-3-27 09:172 t" Q9 z, q: t8 `  V1 `' i, |
hypoxia maintains stemness or carcinogenicity9 H3 b1 ~6 T* i
2013-1-2 05:21
% x1 x# w) _8 v: vcancer is the living fossil records on origin and evolution of human being( ~' P6 B( m2 I, a1 J  _- S/ [+ C
2012-12-9 23:31
! }0 d7 Z+ |. T# {7 P4 S" i' Vinformation island results cancer/ }+ u3 |8 V/ B! C9 e5 g" D$ Y  l4 A
2012-12-9 05:23, \/ Y$ y" `1 x' N! J$ [% ]/ {+ J
life is digital game
3 a: Y5 V& w) _% P7 q' B5 A2012-11-10 00:17
( N! x5 ~' \- u% v# {  [8 ]# e4 S8 Acancer ——severe abstinence reaction of cells to niche addiction. _# H* E, i; f0 W$ I
2012-9-28 12:11
! N) ~9 T& G9 f* B4 A4 m8 l未来生物学终将回归物理(熵)及数学(分形)的美感( c1 f( J9 t; j( O
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)9 g3 m+ E6 y" T# e0 L
2012-9-25 21:22
  H2 e7 f3 J; Xmembrane holds the key to life
2 u+ p0 h" M0 s5 I2012-8-19 20:24
- H, O( z! q  {3 P* iCancer is the default state of cells& p/ I2 U, {# u
2012-6-26 22:17
/ W/ m! S! l; ]mainstream cancer theories could be overthrown！$ z* F- n8 g  Y2 o" [- x
2012-6-25 15:43) l8 d, ^. Y% V, Q8 p( Z9 O
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming.... P$ F1 r6 F. u
2012-6-7 09:36
" u: d! Z$ a+ |9 ]9 B7 ~$ }! l& ievery living organism connected with the water， one cell one world/ C! Y8 N9 u7 r
2012-4-19 22:06
6 f( w( }! Z! ]' ~: x0 v6 ichemical structure of cancer cell determines it's biological function...: `$ Z0 j: c" y! |1 ]5 Y, N! B
2012-4-7 17:564 j4 \6 n. D. o% p5 ?6 D  @. |; ]( y
Mann tracht und Gott lacht
& c' s9 [2 m/ G( Y. p' q2012-3-24 21:34' z. R% x8 m! h% S
Darwinism or genetic determinism is a fairy tale！
) y0 |2 H# }! \  |2012-3-13 15:18
- o- Q$ V' v. F! xniche isolation is essential for cancer speciation' F% x4 x9 L8 `# N& i
2012-3-12 12:07
& x/ M# q' p% h% r, T. [' q! jHybridization Creates New Species，Mutation results species extinction6 }  Z  l# i& a+ }' n
2012-3-11 18:21( E0 d" C: \( R& C1 j$ W4 M6 x
ROCK may join the niche reprogramming...; ~+ O7 F1 C1 d/ V4 A
yuhaoze: 这是篇文献吗？ (3-9 10:41): V" ~( ^2 K2 |9 m1 g
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
  ~% Z) D" ^' \yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
& E6 z9 U. N5 s0 q2012-1-19 10:52
. C. d' E! w, A% T2 |  I; \, T% j( koncogenes are pseudoscience
; Z# S- f- p( l2011-12-29 13:55
1 ^& x; z4 N# M1 t' g, x. n/ W5 Cgene mutation leads to variation or extinction, not new species
0 m4 d  y1 S% L  Z/ G, K* A2011-12-29 13:28) k2 Q. k& |" ^5 J
oncogenesis is non-Darwinian event
# m" h$ k+ x4 R3 n5 t/ \2011-12-28 22:567 K. ?4 o- Z: f6 C
disorganization activate neurogenesis activate oncogenesis   
) Y/ F9 e6 P, ^- ?# V2011-12-22 23:38
; a% M4 J8 w, p: }' e  x) CMSC is cell feeder，tissue scaffold，immune firewall and biological glue# J3 j- l' x, r$ n, @) G2 a4 H
2011-12-19 19:461 B# }* D8 \1 J* g! p
cancer is Noah's Ark（species carrier and life explorer）
" e8 r+ U6 u# {8 t# |2011-12-10 09:46
/ _/ w  E6 N1 g! f# v) ucell fusion create new species, gene mutation induce variation
& Y9 I/ j! O* }' n& A2011-12-10 09:36
- d$ E+ d. [, d$ v& ~: p% KGVT will be cancer terminator， Cytokine storm will be cancer preventor
7 K, D6 H4 E( y* n; [2011-12-8 12:56
+ X' K1 u: \3 L6 Ccell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
/ t4 Z# j+ \) L' _* F2011-11-27 14:54' ]' o" r. l9 x* p: Z
Cancer is between protozoa and mesozoa， not metazoa...! i$ q' D; O4 M! Y
2011-11-27 00:25
/ ~% ~2 n9 d8 }: T, g; F' icancer is neurological disease！ haha，I got it！: B! F4 N/ |, E% L$ `: E0 _! _
2011-11-22 22:06
* ^' w) Z4 A1 r7 ^- k  myou are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
0 Z' \, E4 z& h2011-11-12 11:27
+ ~2 S$ h, p9 j) J6 h0 m+ }9 tcancer is the ecological invasion of hacker...
( V6 }. F  g% e; M* z0 K( Z2011-10-5 10:31
' S8 R1 A* |7 {4 L' c* E, LmicroRNA is  negentropy？
6 E& r& S% Z' y" o2011-9-24 00:48' K$ m) ^0 x2 n" t3 L% U) `
cancer is the social problem3 G+ c6 f$ X) K+ ?3 D, v
2011-9-9 23:333 a2 N/ B- v5 g3 E
Science is the games of nobleman or madman
8 U+ s5 h5 ]8 H2011-9-2 15:03
2 I+ y. r) s1 Fcancer resulted from disturbance of biological liquid crystalline state of ECM
8 Z8 K* e6 i4 Y5 F. ]2011-9-1 20:13, t2 E1 ?9 V9 `! D, r
niche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...& z7 x1 ]. C3 a4 W9 U' k
2011-8-13 00:37) u' ?5 f; V; M! \8 a6 L  f1 d( X
Second recession is coming？4 U, Z4 u( L2 L2 ?- e
2011-8-9 23:584 H3 s4 m8 ]% ~0 ^. D
cancer may be from sexual reproduction of somatic cells.
) M* c: {8 I4 }1 |2011-8-7 00:16- N! j8 @, t: V7 E  y9 y( V  q
who determine gene？ genetic determinism is fatalism！
* j( w' C' z+ N! v& R$ y1 K2011-7-30 11:26
7 A6 h* X( B4 nniche reprogrammabllity is the key of solving cancer problems...4 @! m, D7 r; X" |6 ~! c2 E7 A
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)4 u% y' h) r) D* i1 l7 Q; R
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
7 s  L. C3 c3 ~9 x3 Q" }7 ~2011-7-24 01:24
( @5 `, s( ~, p& gcancer results from acquired genetics alterations.- E; \! Y* _# |. {3 a7 a+ T8 K4 D
2011-7-20 21:373 o' ^9 B! j+ O/ V* C1 o8 i
CSCs are the low differentiated cancer cells in G0
% y+ Y4 \* `$ T4 q4 L' m2011-6-29 16:30
+ H6 h6 k& F. j% K- }9 siPS future——in vivo direct reprogramming ...7 X6 r( b) l  X+ Y1 e3 i! _
2011-5-31 15:20, x$ J/ @: l1 q" T8 ^
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html% @- \& U1 i3 t' |
2011-5-31 01:28
) i4 R+ E( s# W0 \, Wall the somatic cells of Mammals are totipotent ！
) @. k5 s# }% h4 K9 v5 o& `5 f* W) }7 ?2011-5-22 22:224 Z8 P" c6 {. f' `+ G8 S1 x
miRNA——The manipulator of  cell fate！
2 \% v4 W& p$ }6 G1 N( |8 d* |2011-5-20 20:21$ K( ?& l& p$ N0 `
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
6 O) r9 F4 g$ N/ J5 P2011-5-17 12:38
0 ~9 ?0 s! @* ]# vcancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
! f4 q4 C+ f7 C$ e5 U2011-5-11 12:31
' S: b) p& `7 mcancer results from cell dedifferentiation.../ Y! H6 `1 |- q6 K& ]& i6 I
2011-4-28 18:07! P& E7 j2 S, E4 m# r
differentiation——asymmetric cell division ！
; K3 l+ h4 r* f1 B& r- I% m: C2011-4-28 18:04
+ T1 v6 R& d- @. V/ Kcancer origins from the regenerative cells！+ x4 p! @" P. h
2011-4-28 17:528 A3 i9 h: J  m! m( n4 r7 v
Proliferation is differentiation potentiality！6 x. I3 O) x3 Q- n2 ~, v! z
2011-4-28 17:49
$ y2 M5 ~$ |; S6 `% N; D4 Z6 ]iPS——the key of Pandora box！$ G3 u0 L$ f4 g! J% a8 S7 O
2011-4-27 22:36
' _; S/ S6 l* Z8 |Aristotle— "The whole is greater than the sum of its parts."/ w3 t7 d# D/ d, b+ t
2011-4-27 00:20) t6 n* V* i& v# Q  `
cancer——atavistic cells$ E& E$ X3 f& w# t
2011-4-20 00:20
- l0 n0 a( N5 E& v4 j! d1 ycancer——cellular atavism！' t7 G' @0 u6 z! [$ x6 E; c
2011-4-20 00:18
5 {6 |6 a4 H0 i) f" G8 W! H/ fcancer——evolutionary ancestors of mammals.0 [0 Y, G! O1 ^
2011-4-20 00:09
) C3 g; Q$ w' Q* F* X$ l2 `% i肿瘤是细胞自组织缺陷的产物 ! }' @. P- p) A5 h; D8 F' H
2011-4-17 01:41% I: H& {! w- a; |- V
cancer——Metazoa 1.0, U/ @0 l/ f& u, q( m6 V. c
2011-4-17 01:00- L+ P) i& `" d$ ~+ s, f
US——the Axis of Evil！
; @5 g* t9 U! {; N2011-4-4 01:19
% d+ ~3 f* p# c$ {7 x. h美国是世界的邪恶轴心！* v# M) ~7 H0 W+ c
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)- @3 `: u3 m2 K2 f% m
2011-3-22 19:06: O5 Z4 S, Q: A7 ^
teratoma is derived from endogenous iPS！* v6 N0 \0 e. X* s5 e! E
2011-3-15 21:44  I6 n& H) g6 K3 O  |
ips is a luxury gambol on  
. \. \" y# i4 w$ Z* c# w, c/ k9 H2011-3-3 14:50' x8 d3 s+ K6 d! L& l& f1 A* [8 S
cancer is intermediate of species evolution6 u  r1 s4 J1 \1 @* s! V
2011-2-12 12:29
0 o* B0 O5 i/ {9 vstem cell now is on the eve of coming medical revolution+ y0 M2 T0 ~! p, _. k4 u
2011-2-12 11:20
! t3 c* F/ |) _: cInflamation is the reprogramming process of somatic cell in vivo！
# T# p  m" |2 ~  J2011-1-31 14:49. c* y$ i" M0 p$ h
so-called medicine is niche regulator！
5 U# k; l+ h7 \; J) R" n2011-1-23 21:45
- S8 [. ^9 X7 n' o! ]! vendogenous iPS is the cancer initiating cell！
, ~3 k! ]# Y2 Y* ]; n! [; Z2011-1-17 16:47% X8 X  c# D# O1 W
cancer is unicellular organisms！
$ B, y9 H) [; }: h2011-1-9 22:043 F) p! ^  h7 O; E/ j9 U% i: ?$ @
Pandorabox Has Been Opened) H9 S1 u* @& h5 w6 C$ ?7 n
2011-1-7 23:246 B# W7 v, w) ?: d8 A. |
iPS is the Emperor's New Suit ! 
* L8 d0 H6 x$ ~2011-1-5 23:50# D& z9 O* W1 o5 V7 {. a0 {
cell-free is the final solution of stem cell therapy
- p1 Y, [( F, i+ `* v% h6 d2011-1-5 21:46" U+ T# u" e! L) H* x
niche is telling the story of stem cell...4 U" S) s; b% h. z. }
2010-12-29 17:32, `+ u4 D! Z% \
cancer results from reprogramming of somatic cells* T: R8 e: q$ d/ m# n( c. h
2010-12-25 18:56
2 u9 h4 d6 n% S1 j' W6 e2 `% @cancer——good cells in bad niche！' J' t' Y* ^" @/ L, E" K0 L2 V% Z
2010-12-25 16:021 w# r$ v6 g. G# k# X! I
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
6 G; w7 k- N8 \: O0 D' m7 jderon: 灰常同意，有相关文献么？ (12-19 09:41)
, _8 W: L8 k, i% Usunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
9 Y9 l9 B; I- l) H, m8 Hsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
6 G+ K* R" _' T1 a0 |2010-12-18 15:547 I5 D  Y) R% m' }) |3 ~  ?% e+ x
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
7 m/ V( ~# A; T1 h2010-12-15 15:07/ e. c: `- k- Q9 X9 J8 D4 Z
老狼的记忆——大洪水* v% r- _0 D( G/ v0 f
2010-12-13 23:25
) _: W9 z5 D4 ~can cancer randomly differentiate into norml cell in vivo  
5 ^( y- N6 b1 y  q- Q2010-12-13 22:33. N: S# w7 G/ y2 w
omnis cellula e cellula
' Y* T  s* ~  q4 d3 @8 ^2010-12-12 09:28
% }0 @5 K' ^7 `/ w  @/ CStem Cell ——The Origin of Disease
" ^' e6 _! j  m" P9 d2010-12-12 09:27
1 w2 N7 k" n9 ~# r

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