老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
: e. u! K" a% S8 o2017-12-1 13:17
2 s9 m) V0 p) x) L: q9 x8 SBioreactor in vivo would be the terminator of illness.7 Q, V# U, q: L$ X" m" C
2017-11-20 23:09
0 G9 X$ X0 S* ?1 B! Vrenew tech：剔除衰老（病变）细胞占位可以恢复青春。' U) D- c# f5 l. s1 a) J2 S
2017-10-23 12:50
% {$ ?2 u2 a+ |! M1 s; w" H魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。( r2 N. F: R8 I) m' m
2017-9-30 10:58
- _, w0 Q7 I$ F4 s: ^! h% i4 F% DLife 3.0——from decoding and coding to reading and writing. Z& ]- P9 {) h/ a. ]
2017-9-21 22:32$ s  u: x# ~! |  ^3 ]1 E- l, A
理论创新：亮明立场——先颠覆，再完善2 t7 {. s( ?& M
2017-2-7 00:07
& ~" f* _2 j$ m" M7 P干细胞第二定律：与细胞外基质共同构成多潜能；6 b9 G, w. l, i( U  q0 A: a4 m
2017-1-3 11:14
, T4 T3 c# }: M干细胞第一定律：全生命周期保持增殖分化能力；
' D% A9 U# s) {+ l+ G2017-1-3 11:13
& k# b. w4 |/ Q& M/ J( KNgAgo——Never give A guideline operated！
  @3 @; e# |! _  N* F2016-12-1 10:09  S! j7 P; K( M' ~5 |" [3 `
表观遗传—— 一切皆可改变  一切皆有可能: C7 }. L: m- q# B
2016-8-17 23:37
+ g) b& P; _6 k8 o3 `$ y) l子曰：吸血鬼疗法——养儿防病 养孙防老4 x$ U% Y: f& e8 U( U  T
2016-5-23 12:05
0 i' Z1 U% s# n/ w/ m! hNgAgo——Debug tool kit for mammal cells
, ~$ Z+ R3 v' o% l( R2 Q2016-5-9 13:098 X) X2 a' P3 G  |$ G( D$ g
公理之外 皆需证明； 科学命题 皆可证伪。( M! F" Q# d  m& v1 J
2016-1-2 00:209 z- x  M5 J$ H, P: {' A, O- f
低氧——破坏线粒体功能、诱发炎症、导致基因突变) m' D  s# K; ^
2015-12-16 20:19; s) y. T% ~& u2 c5 W! O% d7 F
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。3 c6 e( r7 I! l$ ?6 p! h# `
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)$ w* ~% O$ v4 C, Y" D
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
9 U1 N$ |- L+ Y2 ohcoohboy: 3ks~ (12-24 16:45)
/ D* M% X) x8 i* \" Y/ u6 i2015-11-18 15:54
7 q, x* G* F( d7 l1 q4 }  v* D: E* Q抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
6 R6 g$ ]- J: w/ r$ L$ M2015-5-20 14:13
. {9 e* y. |2 X. @) f 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学$ O* |& [" t$ _( g- H
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
# W2 r2 T7 P; H. }: B) M2 u+ l5 fsunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
) T; A3 w* M4 n$ H2015-4-21 16:46& b8 X$ i& _+ y8 Y$ x* x3 X: ^
search and research is just disassembling the creature.: D  Z4 l/ b- t! }
2015-4-7 17:01& z* Z: F# P% l
selection is  the act of intelligence: O+ G4 `! P/ ]. U7 F
2015-4-7 13:49: Q( W( m4 g3 j2 F, \3 f5 |
Genome fusion create neoplasm2 g) |$ f( m8 q, _" U. L
2015-1-20 13:101 q, t0 V* j) v7 }* B
STAP——Stupid Trick  Against Professional 
7 C; s  f1 S/ l$ s% _* s5 b( \2015-1-1 19:29$ T6 }* n4 E8 A) B5 c6 n1 r3 V, C
information=structure=negentropy3 `0 ]5 E! \6 M! L
2014-7-22 17:36' b: t) E; ?# e( R& }) @
Natural mutation does not result in new functional genes % a8 y) Y9 S- U. V2 ~
2014-7-3 14:06
$ U+ g4 i& J9 i% A+ |life is wisdom creation instead of natural evolution; n" ^$ G7 R# K+ `; a/ o
2014-3-27 09:33  l/ ~, ?0 p9 N7 F$ R
let us explore the source code of life !
! X" |! W& y  X' q- f$ r, Q2014-3-11 13:11
. D/ B" L1 Z, V$ F  A( _0 fbio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.  p/ [/ M8 G5 c& |+ e; @5 @
2013-10-7 23:068 g% B. B  _8 Q$ s8 H
induced abortion would give the key for curing cancer 8 R. N9 e, Y* Z% ~
2013-10-2 23:335 L) ?" g) @3 }
“key breakthrough” in molecular biology are entertainments
- k9 k5 p& a' h! o! X5 [2013-6-16 11:50
3 g0 E" s% h; H+ P# @) v% l: xRules Of Living：trial-and-error exploring，survival takes the legitimacy
" w& ~5 U6 y% W. ?% q7 q2013-6-16 11:275 D/ N, O* H: f* n0 N8 t& }
Life is a set of debuging programs
  {3 J- D. }# R% f2013-6-15 18:40' d( [- i3 H2 \7 a, w! _7 ?
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells
, p9 P( d9 _3 W3 ^" H! x3 M2 p! ?2013-5-2 08:54
' S. p. {: s- V$ R& {. sinformation，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
% J" q5 U1 J( i5 ~. r2013-5-2 00:515 L" c4 v: G& q8 ]# f4 b
virus is the messager of  the universal life network! _* B3 u( |6 I' d
2013-4-18 14:33
' Y1 l' `. @$ H# D0 _Genetic information doesn't improve cancer risk prediction8 l! N% j5 C3 t1 f6 A$ D
2013-4-1 09:20  D/ ?( ?& u% N; J, ^* y3 Y
There is no early diagnosis of cancer，but early prevention of it
  F# t4 E* b1 _# f) J" K2013-3-27 09:17
4 h* L  L! Q% i+ i- I3 bhypoxia maintains stemness or carcinogenicity
* o+ ?" @$ y% W# J- ?( J6 c2013-1-2 05:21) [! v! v& a) H9 W- k1 n
cancer is the living fossil records on origin and evolution of human being9 I+ a$ {% u$ r/ J" q
2012-12-9 23:31
6 x# o. h; A4 z6 O$ g$ Qinformation island results cancer. D& O5 B3 K: C- W8 N3 Y
2012-12-9 05:230 ]# s, r# j8 [5 ^' A6 k$ A9 B* Z3 Z
life is digital game
  X# y  N+ _. x, Q9 h2 l/ n2012-11-10 00:17
5 }, k2 y3 H/ W- x$ C' |cancer ——severe abstinence reaction of cells to niche addiction6 j$ l- w3 f+ g/ c5 H, ]) L7 }
2012-9-28 12:11" E( ^! m, ^* n, l) O( Y9 s4 `  M2 N
未来生物学终将回归物理(熵)及数学(分形)的美感
+ t! g# {% k8 q' m# H2 Nbiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
# p; d5 l' {: y( _& B. \& H. |# M2012-9-25 21:22; e& U4 r2 N8 D5 E  Z, `) o# F
membrane holds the key to life/ @# \/ m& c( J) O% y. Q4 P
2012-8-19 20:24
# d4 X, `$ A$ K( W/ MCancer is the default state of cells7 y9 M3 `6 t8 d9 l, {! w: _9 N
2012-6-26 22:17
. ^) g1 |4 F+ c$ cmainstream cancer theories could be overthrown！
% R, K3 w8 T3 \/ L2012-6-25 15:43* Z: ]& i# d+ r0 i; ^
carcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
* _  H" u9 c% r8 b. `# L0 a" P2012-6-7 09:368 s4 l7 R0 F. d: M7 p  b  P, I- y
every living organism connected with the water， one cell one world0 J" l) ]+ i9 ~$ g0 Q
2012-4-19 22:06
6 ~9 i5 i+ B, s. x1 lchemical structure of cancer cell determines it's biological function...
" r: G, t5 B$ p" @* H8 O2012-4-7 17:56% |! q; o5 U2 n8 p# K. A8 f
Mann tracht und Gott lacht
" C% z. i% U9 x1 k2012-3-24 21:34
. Z8 t0 K- i2 G! t: ]0 x! F4 A. T3 ZDarwinism or genetic determinism is a fairy tale！) a! j1 p" n) n. M  @7 n
2012-3-13 15:18
# }) m2 d" [" ]) c' p. g  ~4 o+ aniche isolation is essential for cancer speciation
  {, o  R+ g2 R& z$ E' \( Y, ^# ^2012-3-12 12:077 Z& I9 q" K8 {) a7 m8 G- _5 @, S
Hybridization Creates New Species，Mutation results species extinction# n% `7 Q* `1 R' x% q0 G3 V
2012-3-11 18:21. Z1 z6 \& ~' C- l* b3 ~
ROCK may join the niche reprogramming...9 u9 ~2 z: I! z2 m
yuhaoze: 这是篇文献吗？ (3-9 10:41)+ Q* L+ h8 L4 ]" h! U. ]; ?' E
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
0 }) W- i' B9 @" E/ g* q) ^yuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)* W5 E' w! y% c/ I: |: F
2012-1-19 10:52
+ ]* ?% g: X- f) h& o3 Goncogenes are pseudoscience
9 r% H) Y9 R* V* u2011-12-29 13:552 s8 h% C- v* k/ S/ E
gene mutation leads to variation or extinction, not new species% F1 A) c( @" P- J+ t
2011-12-29 13:286 P( M& W! q( b* [- P" U9 ?  V
oncogenesis is non-Darwinian event
1 j! Q9 ?$ h6 k* ]5 G' l* i2011-12-28 22:561 b! q7 S. ?9 i
disorganization activate neurogenesis activate oncogenesis   
+ i0 O* N* `* A2011-12-22 23:38
2 f+ j8 F$ Y  D! T, GMSC is cell feeder，tissue scaffold，immune firewall and biological glue1 v. J) {- e5 T( O  D1 [' n& `
2011-12-19 19:46
$ m" g) Q4 s; ]  N$ ]2 e/ fcancer is Noah's Ark（species carrier and life explorer）
) [1 j/ B! h2 `1 l5 Z4 s/ C2011-12-10 09:467 Y9 Y& F. T* h, R: T# c
cell fusion create new species, gene mutation induce variation0 m" S  T0 l: u5 w3 p/ n2 Z- W
2011-12-10 09:36
7 ~! {$ D5 c" o" g$ Y. \GVT will be cancer terminator， Cytokine storm will be cancer preventor, p$ O) h  }) }2 n
2011-12-8 12:56: M& C' G. T, O* w* ]8 ?
cell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
8 z  K& ~$ X* k" e3 v, ~, K8 u4 |2011-11-27 14:54, _/ O" l' v) F' y
Cancer is between protozoa and mesozoa， not metazoa...
5 C# G  y1 {& q! u5 g( e2011-11-27 00:25$ d1 I4 Q/ V4 }
cancer is neurological disease！ haha，I got it！. ^! x. I1 b) u; r4 Z- s9 `; @
2011-11-22 22:065 K: V# R+ X6 |1 R
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来" z( O5 z( O7 i0 E
2011-11-12 11:274 ?! [! a3 g, v; k, N
cancer is the ecological invasion of hacker...% Q1 |( d! i* b! t! X
2011-10-5 10:311 ?) H( [5 [( H% d6 P
microRNA is  negentropy？& v1 Z& E5 V: A6 K& \
2011-9-24 00:486 I# x. W& I1 u' A; Y0 n' S) B( W
cancer is the social problem
: h" Q% S4 }6 \8 L' u2011-9-9 23:33
: K  U0 z) i8 p( QScience is the games of nobleman or madman
2 y: n0 E0 q& N! X/ {) A  u: w2011-9-2 15:031 M* @6 m, V) w* i) Q
cancer resulted from disturbance of biological liquid crystalline state of ECM
9 }' }1 w7 L. M# K4 h& X2011-9-1 20:13
4 K/ `: r9 k$ R' O3 i" A$ Pniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
9 k+ c3 x) Z: q$ T' ^2 I2011-8-13 00:37
5 s* m/ Z- W9 Y9 u5 {; V- ~Second recession is coming？; ~. c3 H% Z$ f/ l* T$ s
2011-8-9 23:58+ Y3 k2 b2 J' n! d. \7 z4 X
cancer may be from sexual reproduction of somatic cells.1 \: f5 v* L- n8 J- u- w5 j' P
2011-8-7 00:16
. }7 V9 f8 \) N8 c0 y7 \who determine gene？ genetic determinism is fatalism！
1 y9 d7 }- Y1 [8 X" p, F7 U2011-7-30 11:26( A2 J+ H, l" X2 k: L
niche reprogrammabllity is the key of solving cancer problems..., P* v4 z6 s% Y6 J
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
* h/ k' n2 ?7 G+ c* hsunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)8 \% e' ?6 Z& L5 d/ `
2011-7-24 01:24
. p1 k; W3 K" |cancer results from acquired genetics alterations.* E3 y4 d& e& Q$ f" D( M! b4 U
2011-7-20 21:37
9 ^, O1 p5 @, T# t8 xCSCs are the low differentiated cancer cells in G0& A$ ?5 t& ], K0 A& p- c# n8 Z" t
2011-6-29 16:30
: w2 I; N( m- y& ?6 ]9 |iPS future——in vivo direct reprogramming ...
1 E# O2 R9 a7 V% t# E2011-5-31 15:20/ r! S8 q* g; ?  K
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
; W8 Y9 G7 n8 a. d: d! I5 ^2011-5-31 01:28: E0 }1 e8 ^& ^6 H* H
all the somatic cells of Mammals are totipotent ！
  }& O5 ]0 X0 `$ k, @* f2011-5-22 22:22% |/ D7 d( j$ X" ]
miRNA——The manipulator of  cell fate！
, `, s5 Z6 {% w% @1 C9 {2011-5-20 20:21! a: G, D3 [2 O, p2 O6 e$ {8 {
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
3 J- \1 ^  _8 S* m# {2011-5-17 12:388 ]) @$ O+ b& f/ N' k
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！
1 v( v% k1 n0 {$ D8 N2011-5-11 12:318 S+ N" Y6 E) q  p( W+ y* F
cancer results from cell dedifferentiation...
" j  R) ^2 ]7 C6 Q, h; E+ L* ]2 n2011-4-28 18:07& z1 g% W) V; ^+ g0 z& _
differentiation——asymmetric cell division ！8 J+ ~" \: \$ `
2011-4-28 18:046 T# I2 q; L7 B3 w- I/ i
cancer origins from the regenerative cells！
. A. ]7 o7 A/ l+ Z2011-4-28 17:520 s" a# F& e, @, \3 v+ J' t. I) u
Proliferation is differentiation potentiality！
0 q3 \/ W$ G- N7 J0 f2011-4-28 17:49
5 _0 f& M2 [0 ^' ~iPS——the key of Pandora box！; N! X1 [, X3 W! q* L$ W
2011-4-27 22:36
4 c7 j2 ?- \6 n* u$ V0 F: k  {Aristotle— "The whole is greater than the sum of its parts."
8 i9 n& a* L/ E# D+ F2011-4-27 00:20
' ?3 ~! g6 o7 E1 w" fcancer——atavistic cells
1 t  k' {& H; s2011-4-20 00:20
, A8 w3 b6 B% v* ?8 S( Ocancer——cellular atavism！
3 y) a) ~! g; E" v: z3 a- _2011-4-20 00:180 L3 R3 @' U' d- n: p, b
cancer——evolutionary ancestors of mammals.
7 U0 l# {5 T* Z- \% a! I: Y1 x2011-4-20 00:09% ?* ?( O' P, d. y) U+ Y9 I
肿瘤是细胞自组织缺陷的产物 
& U% u& L9 x! v0 D( U4 h% ?. b2011-4-17 01:41
9 o) s* ]5 k5 c6 p6 E/ a0 q! c7 {. vcancer——Metazoa 1.0) \- [/ A/ e& ~: \* J
2011-4-17 01:00
8 X, m! c6 u8 i! vUS——the Axis of Evil！
, B/ K# \4 O% j( d1 p2011-4-4 01:19$ ~. d2 G1 c. O
美国是世界的邪恶轴心！
3 T+ ~) [, Y+ H0 f, Y" E8 J3 a" Csunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
* o- @& p4 Q7 w! A! C2011-3-22 19:06( Y- s* D  M/ y# B
teratoma is derived from endogenous iPS！
7 \) k4 X0 T0 f& g8 \2011-3-15 21:44
/ L+ b7 n: i7 k9 m0 K9 h6 wips is a luxury gambol on  
7 \! |# z. C4 R3 s2 u2011-3-3 14:50: \9 V$ I2 u' z3 G$ e& K2 c
cancer is intermediate of species evolution* S% c+ \+ H2 u# @- a% z
2011-2-12 12:29: f9 ~  u! t0 w* m
stem cell now is on the eve of coming medical revolution
( B! x, H% u6 u1 V: w2 t( J* a2011-2-12 11:20
1 c% V7 d& w3 O7 L  _Inflamation is the reprogramming process of somatic cell in vivo！4 y- x* ?) Q& i; H
2011-1-31 14:49
" l2 U5 r$ U  J( }: V, [so-called medicine is niche regulator！
) W( w! _4 h' }2011-1-23 21:45
  [% N0 o8 X  F. k. k5 q6 Rendogenous iPS is the cancer initiating cell！
+ L' I7 T, U3 l: i+ D2011-1-17 16:47
  P. u3 y0 ]# O8 F8 e6 {cancer is unicellular organisms！8 B, v  \) y: k! S
2011-1-9 22:047 {/ T$ ?/ o& o$ E- X8 o& x# |
Pandorabox Has Been Opened* [$ M5 G1 j9 _# T2 m" D
2011-1-7 23:24/ f4 O6 U9 b' j" m2 K" `
iPS is the Emperor's New Suit ! 
3 n2 }: E4 ?/ U* U2011-1-5 23:50: I1 C. E, X$ b2 C
cell-free is the final solution of stem cell therapy' j. q' R4 u7 t, t1 K+ r9 Z5 |
2011-1-5 21:46% d, [. V1 F6 Q+ u3 w% ~  d( m
niche is telling the story of stem cell...2 O  ?5 P8 Z. T. q  z% J1 G
2010-12-29 17:32) G7 g$ C; d/ E4 T* S' Q  y
cancer results from reprogramming of somatic cells: e1 R( F4 M; I  T
2010-12-25 18:56
* u$ L( }  F; K: q" U& u4 rcancer——good cells in bad niche！% D' o! h1 m0 x' H3 ~, P
2010-12-25 16:02% o3 g4 z7 {* j
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！
  N5 q8 p9 m# a, J' e+ Y( G9 ~) @! @deron: 灰常同意，有相关文献么？ (12-19 09:41)
( V1 ?) C; n; S" c# `sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
* v0 ]- F$ y0 R! Q" b: Y/ Vsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
6 E  }; ]& V8 v2010-12-18 15:54$ p: _. A; F! C* `% s
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！
, }) R) m9 f, R$ i# z& O0 [2010-12-15 15:07
6 F+ ^2 u% [# f* o老狼的记忆——大洪水
! ]# \$ r/ j5 }' ]" Q6 b% x2010-12-13 23:259 v6 Z7 d6 P3 @- C0 a
can cancer randomly differentiate into norml cell in vivo  & k" ?8 E7 [! D4 f
2010-12-13 22:33
( M3 J$ I# t  \4 `omnis cellula e cellula: U6 Y3 o9 b* [5 ]: G
2010-12-12 09:28( q% ^$ a! Q' K8 _/ S6 t
Stem Cell ——The Origin of Disease! K. N! \9 l6 g
2010-12-12 09:279 ~! T4 l# ^/ R' r0 P, F

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